Naso-Maxillary extramedullary plasmacytoma: a case report

We report an early case of extramedullary, right maxillary sinus and nasal, plasmacytoma. The patient was a 27 years old female who presented with nasal bleeding and a nasal mass. Imaging studies showed opacities in the nasal cavity and the maxillary sinus but there was no bone involvement. A biopsy from the nasal mass showed a plasmacytoma. She was investigated to rule out systemic disease. The investigations included; serum electrophoresis, urine analysis for Bence Jones proteins, bone marrow aspirates study and radiological skeletal survey. The results of all investigations were negative. After complete excision of the tumour endoscopically the patient was treated with adjuvant radiotherapy. She remained well, without recurrence or spread of the tumour at 4 years follow up. CT scans pre and postoperatively as well as H and E and Immunohistochemistry slides are presented. To our knowledge, this is the first case to be reported in Sudan

Study the hypoglycemia effect of nigella sativa at the experiment animals and its comparison with olive leaves and oral hypoglycemic drugs

The acute hypoglycemic effect of Nigella Sativa seeds was investigated in alloxan or streptozotocine - induced diabetic rats. A single intraperitoneal injection of water extract of the whole seeds in a dose of 400, 600 and 900 mg/kg lowered the glucose level significantly after 2 hours and the effect further increased persistently after the 3 and 4 hour following the injection. Also we compared the hypoglycemic effect of seeds with aqueous extract of olive leaves, and the results showed that Nigella Sativa was more effective in lowering blood sugar. Glibenclamide and Metformine were used as reference. Glibenclamide [3 mg/kg] showed similar hypoglycemic effect to the aqueous extract of Nigella Sativa Metformine [250 mg/kg] was more effective in lowering blood sugar than Glibenclamide and Nigella Sativa. At the same time the daily oral administration of water extract of Nigella Sativa [2500 mg/kg] showed a significant reduction of the glycemia after 7 days of treatment, and the blood sugar continued to be reduced constantly to the end of experiments [23 days]

Styryl and dicationic cyanine dyes containing the pyrazole moiety

Three types of cyanine dyes containing the pyrazole moiety have been synthesized and their visible spectra were compared. These include symmetrical dicationic dimethine cyanines, asymmetrical styryl cyanines and asymmetrical dicationic cyanines

Synthesis of some new pyridyl beta-lactam and thiazolidine derivatives

In search for new Beta-Lactam derivatives of modified antibiotic activity we have investigated the incorporation of pyridyl nucleus onto the Beta-Lactam moiety. Several pyridyl derivatives are known to exhibit interesting pharmacological properties as anti-inflammatory agents potentiators of adrenaline, ganglionic blockers, antiphlogistics, and postemergence agents on broad leaved plants. Thus 2-aminopyridine I was treated with aromatic aldehydes in absolute ethanol in presence of piperidine as a basic catalyst to afford Schiff bases II. Treatment of II with an acid chloride and tertiary amino would yield the desired Beta-lactam. The low yield of II in this case may be due to tautomerisation of 2-aminopyridine I/a to the mine form I/b. The presence of an electron withdrawing group would decrease such tautomerisation, and would facilitate condensation with aromatic aldehydes. Therefore nitration of 2-aminopyridine was carried out to afford a mixture of 3-and 5-nitro derivatives III and IV respectively. Interaction of IV and aromatic aldehydes afforded V[a] [R=H] in 37 percent yield. Higher yield was obtained when IV was allowed to react with 4-nitrobenzaldehyde. Treatment of V with chloroacetyl chloride and triethylamine afforded the corresponding Beta-lactam VI[6. The IR spectra of compounds VI showed a well definite absorption band at 1760-1720 cm[-1] [the C=O stretching of monocyclic Beta-latam]. The cycloaddition reactions of thioglycolic acid with the azomethine group in V was also investigated using a water separator system for about five days giving of the cyclic 4-thiazolidinone compounds VII but in low yields. The IR spectra of VII showed a definite absorption band at 1680 -1645 cm[-1] [C=O group]