1-arylcycloalkyl [bis [2-chloromethyl]] amines: alkylating analogs of PCP as possible antineoplastic agents for brain tumors

Novel alkylating analogs of phencyclidine [PCP] have been synthesized in the hope of targeting brain tumors. The compounds were designed to fulfill the skeletal requirements of PCP and those of nitrogen mustard analogs. Chemically, the new compounds would be considered as 1-arylcycloalkyl [bis [2-chloroethyl]] amines