Kikuchi histiocytic necrotizing lymphadenitis: clinicopathological and immunohistochemical study

Clinical, morphological and immunohistochemical features of 10 cases having the lymphnodal histological pattern of Kikuchi disease were examined. Two of these were diagnosed as systemic lupus erythematosus [SLE]. Morphologically, Kikuchi disease and SLE were nearly indistinguishable. Plasma cells, neutrophilic infiltration, haematoxyphilic bodies and vasculitis were not useful in differentiating the conditions. Kikuchi lymphadenitis and malignant lymphoma however could be differentiated histologically. Morphological features that exclude malignancy included: polymorphous nature of cellular infiltrate, absence of abnormal mitosis, preservation of sinusoidal pattern on intervening areas and presence of extracellular and intracellular karyorrhectic debris

Intestinal lymphomas; a clinico-pathological study

Forty two cases of intestinal lymphoma were considered in this study. In 26 cases, the lymphoma was confined within the wall of the gut [9 small intestine, 14 ileoceacal and 3 colon]. In the remaining 16 cases the lymphoma was confined to the mesentric and retroperitoneal lymph nodes. Abdominal pain and/or mass was the main clinical presentation. Intestinal obstruction or perforation come next. Using Rappaport's classification, the diffuse poorly differentiated lymphocytic was the most frequent histologic type [40%] and DHL was the second commonest [22%]. Staging at the time of presentation was available in 20 cases [50% were stage IIE]