Follow-up studies on the effect of a single ferrous sulphate dose or ascorbic acid dose or both combined on hematological and sederophilic parameters in albino rats

In rats oral administration of a single dose of 12 mg Fe[++]/ kg. B.wt. caused a significant elevation in serum iron and was effective in maintaining high normal levels of blood Ht, Hb and RBCs count over a period of four weeks. Supplementation of the ferrous dose with 200 mg vitamin C augmented the increments in these hematological parameters. Vitamin C seems to favour not only intestinal iron absorption but possibly the incorporation of available iron into protoporphyrin during the process of haemsynthesis. Availability of haem could augment Hb synthesis to be incorporated in newly formed RBCs that may also be formed at increased rate, leading to increased blood Ht values

Simple agar gel and immunoelectrophoretic studies on serum proteins in hypothyroidism

Serum proteins have been studied by both simple and immuno-agar gel electrophoresis in thirteen cretin cases and eleven normal controls aged from 4.5 - 12.0 years. Application of the two techniques for studying serum protein in hypothyroidism threw sortie light on variations in the protein components and hence would help in proper treatment and quick alleviation of the manifest complications of the disease. Data showed hypoalbuminaemia, concomitant with decreased thyroxine level, hyper-glycoproteinaemia as well as hyperlipoprote inaemia which were found to be difficult to explain and increased caeruloplasmin accompanied with a corresponding increase in serum copper. A significant increased transferrin level, but with a concomitant significant decrease in serum iron. Normal gamma gobulin level was found in almost all cases. The significance of these results is discussed