role of the endometrial thickness in success of infertility treatment using zygote intra-fallopian transfer method [ZIFT]

Many studies have evaluated the effect of endometrial thickness on pregnancy rates [PRs] in Assisted Reproductive Technology [ART] patients. The results obtained were controversial. The aim of this study is to evaluate this effect in the ZIFT technology output. In this case-control study a total of 90 females who have been referred to the infertility center and treated using ZIFT with the long protocol, were entered into two groups: sucessfully fertalized and unsuccessfully fertalized women regarding to the treatment results, and evaluated retrospectively for their demographics and increase in their endometrial thickness in response to the treatment. The endometrial thickness in response to the gonadotropin stimulation From the 7th to 12th day was greater than 2 mm in the successful group, whereas this increase was lesser than 0.3 th mm in unsuccessful group, althogh, there was no statistically significant difference between two groups in the case of this messures [P=0.178]. Moreover, the endometrial thickness in 7th and 12th days of the Human Chorionic Gonadotropin [HCG] infusion, weren't significantly different between two groups [P=0.372 for 7th day, P=0.096 for 12th day]. Our study declines the role of the endometrial thickness response to the gonadotropin stimulation in the prognosis of the ZIFT for a successful pregnancy. On the other hand, the thickness of the endometrium in the 7th day of Gonadotropin infusion and threshold value of 8 mm in the 12th day that has been emphasized in some references lacked their prominence in our study

Screening of fetal chromosomal abnormalities by obstetric ultrasonography in Tehran, Iran

Early identification of fetuses with chromosomal abnormalities enables health care providers to form an appropriate management plan for each patient. The main objective of this study was to determine the role of ultrasonography in screening and identifying fetuses at risk for chromosomal abnormalities. A retrospective review of 6480 patients from the Obstetrics and Gynecology ward of Firouzgar hospital in Tehran was undertaken. Computer databases of patients were correlated to compare the results of the fetal ultrasonographic examination with the cytogenetic results from amniocentesis. Univariate and multivariate analyses were used to determine the best correlations between ultrasonography findings and chromosomal abnormalities. Thirty-seven chromosomal abnormalities were found in 6480 fetuses [0.57%]. Down syndrome was the most common finding with trisomy 18 and 13 being the next two most common abnormal findings. Multivariate analysis showed significant correlations between anomalies of the central nervous system, heart, face and neck, and extremities and increased nuchal fold, increased bowel echogenicity, abnormal biparietal diameter to femur ratio and the presence of chromosomal abnormalities [p value<0.001]. Analysis of data indicated that the presence of any kind of ultrasonographic abnormality increases significantly the risk of fetal chromosomal abnormalities. It is also suggested that a normal ultrasonographic examination in an otherwise at-risk patient will significantly reduce the risk of fetal chromosomal abnormalities

Ovarian hyperstimulation syndrome [OHSS] in a spontaneous singleton pregnancy

OHSS with spontaneous ovulatory cycle is extremely rare. We report a case of severe OHSS associated with a spontaneous normal singleton pregnancy in a 24 year-old woman suffering from severe abdominal pain and dyspnea. Pelvic sonography revealed a 7-week intra-uterine single viable fetus accompanied by ascites and polycystic enlarged ovaries. She was given indomethacin orally and underwent repeated paracenteses, and then discharged after 26 days and delivered a normal baby at 38 weeks of pregnancy