RESUMO
In a trial to approach the most probable mechanism in pathogenesis of stress gastric ulcer, three specific drugs destined to target the three incriminated mechanisms were selected. Twenty four male albino rats have been included, and divided into 4 equal groups [control [G1], omeprazole [G2], pirenzepine [G3], and clonidine [G4], groups]. Stress had been done by 24 hours immobilization. Incidence of ulceration was 100%, 100%, 66.67% and 33.33% in G[1], G[2], G[3] and G[4] respectively. In the same order mean ulcer scores were 3.5 +/- 0.224, 2 +/- 0.365, 0.67 +/- 0.21 and 0.33 +/- 0.21 with insignificant difference between G[3] and G[4] and a significant difference between each of them and G[1] and G[2]. Preventive indices were 42.86%, 92.5% and 96.86% in G[2], G[3] and G[4] respectively with insignificant difference between G[3] and G[4] and a significant difference between each of them and G[2]. We concluded that gastric mucosal ischemia seemed to be the man denominator in pathogenesis of stress induced gastric ulcer and clonidine seemed to be a potent preventive modality in this context