RESUMO
The effects of captopril and enalapril on cisplatin-induced nephrotoxicity in rats were evaluated. Aqueous solution of either captopril or enalapril was administered orally for 7 days. Cisplatin [15 mg/kg,i.p.] was injected in non-treated rats or with last dose of either captopril or enalapril30 hrs before animal sacrificing. Captopril failed to alter serum urea and creatinine, renal non-protein thiol and malondialdehyde contents. However, enalapril in a high dose [20mg/kg] increased serum creatinine, non-protein thiol. Cisplatin increased serum urea and creatinine levels, renal non-protein thiol and malondialdehyde content. Pretreatment with captopril decrease the effects of cisplatin on serum urea, renal RNA and DNA and. non-protein thiol. In contrast, enalapril potentiated the effects of cisplatin. It is concluded that the protective effect of captopril is a function of sulfhydryl group. Further studies are suggested in determining the role of thiol compounds as a basis for cisplatin-induced nephrotoxicity and its prevention
Assuntos
Animais de Laboratório , Rim/efeitos dos fármacos , Ratos , Cisplatino/toxicidade , Captopril/farmacologia , Enalapril/farmacologiaRESUMO
Desferroxamine an iron chelator, has been shown to be ineffective in increasing the frequency of micronuclei in bone marrow cells of mice on acute and sub - acute treatment. However, a significant mitodepressive effect is produced at the higher dose on sub - acute treatment. The mito - depressive potentials of DFO may be either due to the disproptionate ratio of Fe2+/Fe3+ which is known to stimulate lipid peroxidation or due to total chelation of iron resulting in bone narrow depression and anemic condition