RESUMO
Gonococcal urethritis is one of the most common STDs in men, which in spite of expanded antibiotic therapies, is widespread over the world, the incidence of cases resistant antibacterial components is among the causes for recurrence of gonococcal diseases. This study aims at determining sensitivity of gonococcus to common antimicrobial in its treatment such as Penicillin, Sephalesporins, felodokinolos. Therefore, in this study in vitro-evaluation resistance of this organism to different antibiotic especially 3[rd] generation which have been used as selected medicine for the treatment of gonococcal infections in recent years and cases resistant to the treatment have been report recently was conducted as a background for clinical trials. In this study, the in vitro resistance rates of Neisseria gonorrhoeae to various antibiotics by using disk diffusion methods have been assessed. The study is a cross sectional descriptive one, on 200 culture positive samples during 2 years [2003-2004] in medical laboratory. For analyzing of data, chi-square test was used. Resistance of Neisseria gonorrhoeae to antibiotics were as follows: Ampicillin: 96%, Amoxicillin: 92.5%, Co-timoxasole: 92%, Gentamycin: 89%, Amikacin: 88%, Erythromycin: 85%, Penicillin: 75.5, Tetracycline 59.5%, Ciprofloxacin: 46.5%, Cefixime 15%, and Ceftriaxone 2.5%. The result showed that ceftriaxone and probably other Sefalosparins of 3[rd] generation including oral and injections is, presently, the sole group that can be considered as a select drug. Felorokinolons which were regarded as an effective drug until very recently, have lost their importance. This result is in conformity with regional and international studies. Hence, conducting experimental test, particularly E. test E pisilometery test and determination of [minimal inhibitory MIC concentration] and later clinical experiences at fixed intervals can contribute to diagnosis of resistance of Neisseria to antimicrobial component ion oerliminary stages that can decrease irrational consumption of drug in the treatment of clinical syndrome of Nesseria gonorrhea