Hematological picture and some histopathological changes of albino rats experimentally treated with propofol [diprivan]

Forty adult albino rats were divided into two groups each of twenty. The first group was used as control. The second group was injected intraperitoneally with 2 mg propofol daily for 2 months. At the end of experiment blood was collected on EDTA for investigation and specimens from liver and kidneys were processed for histopathological examination. There were a significant reduction in the amount of haemoglobin, PCV and number of erythrocytes and insignificant increase in the total leukocytic count. The histopathological examination revealed congested hepatic central veins, vacuolar degeneration and leukocytic infiltration in the portal areas in liver while kidneys there were leukocytic infiltration in cortex and medulla

Effects of prostaglandins F2a on sperm cell characteristics and histopathological changes of testes and accessory genitalia in rats

Three hundred and thirty mature male albino rats were used for studying the effect of prostaglandins F[2] alpha on the sperm cell characteristics and the histopathological changes of their genital organs. Sperm cell concentration and their motility percentage were significantly increased in rats injected with 10 and 20 micro g PGF[2]a. The same parameters were decreased in rats injected with 75 and 125 micro g PGF[2]za. Activation of most of the seminiferous tubules and decrease in the secretions of the seminal vesicles and prostate were observed in rats subjected to 10 micro g of PGF [2]a. Higher doses 75 and 125 micro g PFG[2]a induced atrophy of the seminiferous tubules, hyperplasia of the epithelium lining the seminal vesicles and decrease of secretions in the prostate and seminal vesicles

Some aspects of drug interaction A Hematological and histopathological changes of rabbit's uteri experimentally treated with progesterone and diazinon

The haematological picture and the histopathological changes of rabbit's uteri treated with 1.5mg progesterone and 10 25, 50 mg/ Kg B.W.diazinon were investigated. There was a decrease in the amount of haemoglobin, and the number of red cells, leucocytes, heterophils and lymphocytosis in rabbits treated with diazinon and with progesteron and the higher doses of diazinon. The uteri of the latter treated animals showed atrophy of the endometrium. There was an antagonistic action between prgesterone and diazinon

Blood picture of albino rats experimentally injected with prostaglandin F2 alpha [PCG2a]

Three hundreds mature male albino rats were used in this study. They were divided into 6 groups each of 50 the first group was kept as control and injected with 0.2 ml of saline daily. The second, third, fourth, fifth and sixth were injected with PGF[2] alpha in doses of 10, 20, 50, 75 and 125 ug respectively. The control and treated groups were injected subcutaneously for 7 days. At each chosen different intervals viz.1, 7, 14, 21, 28, 35, 42, 49, 56, and 70 days from the last injection, five rats from each group were randomly taken and subjected to haematological examination. The result obtained were as follows: a significant increased in blood haemoglobin and red blood corpuscles was seen in rats obtaining low doses of PGF[2] alpha. Rats receiving the high doses of the drug, there was a significant decrease in heamoglobin, red blood corpuscles and packed cell volume. Leucocytosis and lymphocytopenia was observed in all rats. Inhibitory effect of platelets in rats with low doses and stimulatory effect in groups with the high doses