[ effect of intracerebroventricular injection of CB[1] antagonist on feed consumption in broiler cockerels]

Endocannabinoid system play a critical role in the regulation of appetite in mammals. In the present study, the effect of avian brain CB[1] receptor on food intake of broilers was studied. ACEA, a potent CB[1] agonist, and AM28 1, a potent CB[1] antagonist, were injected into the chicken right lateral cerebral ventricle and food intake was measured 15, 30, 60, 120, and 180 minutes post injection. The results indicate that CB[1] agonist and antagonist increase and decrease food intake, respectively. Also, pre treatment with CB1 antagonistfully inhibits the CB[1]-agonist-induced food intake. The results of the study is consistent with the experiments carried out in mammals