Pervention of surgically induced peritoneal adhesions in rabbits by solcoseryl

Thirty one pregnant female rabbits were used in the present study. For induction of adhesions, all animals received a standardized injury to their uterine horns a preximal part of fallopian tubes. The animals were then divided into five equal groups; the 1st group was kept as a control group; animals in the 2nd group were treated by I.M. hydrocortisone; animals in the third group were treated with I.M. solcoseryl; animals in the forth group were treated locally by solcoseryl jelly which was introduced intraperitoneally to cover all areas of injury prior to abdominal closure; animals in the last group were treated with solcoseryl locally together with I.M. injection. Two weeks later, laporatomy was done to each animal and adhesions were scored. It was found that both hydrocortisone and solcoseryle significantly reduced the adhesion formation as compared with the control group. The inhibitory action of hydrocortisone did not differ significantally from the results obtained by solcoseryl when used either locally or by I.M. injection. However, the difference was significant when solcoseryly was given I.M. concomitantly with local application

Effect of medrogestone on endometrial histology and histochemistry in patients with luteal phase defects

Fifty infertile patients with luteal phase defects were the subject of this study. Progestrone in oil, [12.5 and 25 mg] and medrogestone, [5 and 10 mg] were administered daily, starting 3 days after the probable day of ovulation for 2 consecutive cycles. Endometrial biopsies were subjected to histlogical and histochemical examinations. Secretory endometrial patterns that were in phase were observed in all cases after progestrone therapy. Also, the same patterns were observed in 90% and 70% of case after Medrogestone in 5 mg and 10 mg dosage respectively. Undatable endometrial patterns with early glandular exhaustion and sometimes pseudodecidual reaction were observed with medrogestone therapy. These were detected in 10% and 30% of cases with the 5 mg and 10 mg dosage respectively. Also weak activity of the glandular succinic dehydrogenase was observed on histochemical examination of the undatable endometrial patterns. No Histologic or histochemical differences were noted, when both drugs produce secretory endometrium that was in-phase or 1 day out of phase of the cycle day. It is concluded that oral medrogestone is liable to produce early glandular exhaustion when given to patients with inadequte luteal phase. Such asynchronous maturation may interfer with blastocyst nidation. It can also be concluded that progestrone therapy, albeit inconvinent when administered intramuscularly, is the drug of choice in the treatment of luteal phase defects