Immunohistochemical detection of dentritic cells in basal cell carcinoma of head and neck

Histogenesis of B.c.c. remains unclear, some investigators suggested that it arises from pluripotential immature epidermal cells which may differentiate in several directions to produce a variety of patterns, consequently it may be multicentric in origin. Twenty five cases of basal cell carcinoma of the head and neck region were studied. HLA-DR antigen expression was associated to some extent to degree of cell differentiation, and the depth of the tumor not with the histological subtypes of basal cell carcinoma. Detection of langerhans cells among less infiltrative be lal cell crcinoma confirm their possible role in the efficiency c he host immune response