Effect of natural antioxidants on lead toxicity in rats

The present study was conducted on 40 male albino rats to study the effect of combined oral administration of three natural antioxidants [vitamin E, A and C] on different parameters during one month oral lead intoxication. The animals were divided into four groups: Group one and two were considered as controls as they received sodium acetate 400 mg/kg/day in group one or sodium acetate plus 2% gum acacia + 1 ml distilled water in group two, group three received lead acetate and group four received lead acetate plus a combination of the three vitamins. It was observed that administration of the combination of the three vitamins significantly improved the toxic manifestations of lead in group three