introduction to application of platelet rich plasma [PRP] in skin rejuvenation

Platelet-rich plasma [PRP] is an autologous concentration of human platelets contained in a small volume of plasma characterized by haemostatic and tissue repairing effects. Tissue repairing effects and being enriched by various kind of growth factors, has made them the focus of attention for different procedures. PRP has been effective in bony defects, wound healing and recently for aesthetic procedures in plastic surgery. The purpose of this review is to evaluate and summarize the applications of PRP in the dermatology literature, with particular focus on rejuvenizaton process, advances and limitations of current PRP therapies. We studied literature related to PRP therapy, these include regeneration of soft tissue, skin aging mechanisms, as well as wound healing. Some studies have shown promising results, with favorable outcomes about PRP clinical application for skin rejuvenization. This article summarizes our current understanding regarding photoaging process and the role of PRP in the skin rejuvenization process. PRP has been shown to be useful in skin rejuvenization. Further studies are needed to elucidate both basic and clinical aspects of PRP therapies. In particular, platelet preparation methods, different application methods, platelet mechanism of action in rejuvenation field, interactions with the skin components, long-term efficacy and safety are necessary to be determined

Psoriasis and indigo naturalis as a treatment

Psoriasis is an inflammatory and proliferative disease. Psoriasis clinical features vary from plaque-type psoriasis to pustular form. Psoriasis is an immune-mediated disease, which affects epidermal keratinocytes. Regard to serious side effects of chemical therapy in psoriasis patients, various projects were performed all around the world to find new therapeutic approaches for psoriasis. Various studies confirmed that Indigo naturalis treatment induced long-term remission in patients with psoriasis in all ages

effect of sun radiation on the course of cutaneous leishmaniasis in BALB/c mice

Studies have described immunomedulatory effects of sun exposure and ultraviolet radiation on infectious and neoplastic diseases. here the effect of exposure to low potency radiation of sun on the course of leishmaniasis in mice was studied. Fifteen BALB/c mice were exposed to suberythemogenic doses of sun [mean 180 mJ/cm[2]/day of UVB] 2 months before and 4 months after Leishmania major inoculation to food pad. Control group was kept in the sun protected environment. From 2nd to 17th week after inoculation, size of the lesion was recorded in each group weekly and at last week the parasite burden in spleen was detected. Results were compared between two groups. Seven mice from case group and 9 mice from control group survived up to last week. The mean lesion size was 0.90 +/- 0.59 cm in exposed and 4.01 +/- 3.59 cm in unexposed mice [P=0.037]. Parasite burden in spleen of case and control groups were 5.5 +/- 4.61 and 106.94 +/- 279.76 respectively [P=0.006]. Chronic exposure of BALB/c mice to suberythemogenic doses of sun suppressed skin lesion and decreased the extension of L. major to spleen

[Goltz syndrome with absence of fibula]

Goltz syndrome [Focal Dermal Hypoplasia] is a rare syndrome results from developmental defects in tissues with meso-ectodermal origin such as skin, eyes, mouth and teeth, musculoskeletal and central nervous system. We report a 6 years old girl with FDH who had several features of skin, eyes and mouth involvement with multiple skeletal defects and absence of fibula which has not been reported previously