RESUMO
Background and Objectives: the use of neoadjuvant chemotherapy [NAC] in breast cancer induces a pCR in only 30-35% of patients. We canft depend only on clinical and pathological factors to distinguish the patients who have no chance of a pCR or not. Moreover, the NAC scenario is the perfect setting to study possible changes in TIL levels. Tumor-infiltrating lymphocytes [TIL] [CD] 8+ are essential components of tumor-specific cellular adaptive immunity. However, only few studies have addressed the significance of [CD8+] TIL in patients with breast cancer
Patients and Methods: we assessed the stromal and intratumral TIL, CD+8 in pretreatment core biopsy by immuohistochemistry [IHC] in 45 patients with breast cancer received neoadjuvant anthracyclin and docetaxel chemotherapy. CD8 classified into high or low according to the inter quartile range. Tumors with >/= 50% intratumoral or stromal lymphocytes were designated lymphocyte predominant breast cancer [LPBC]
Results: we found statistically significant correlation with high CD8 and DFS and smaller tumor residual [95% CI, 18.6-22.9; P= 0.01] and [p=0.003] respectively. But there was no significant difference regarding pCR or OS between high and low groups
Conclusion: this study confirmed that the CD8 TIL is an important prognostic and predictive factor in breast cancer
RESUMO
Background: Prostate cancer is the second most common cancer in men and the seventh leading cause of male cancer death worldwide. It is a highly heterogenous disease with great variability in its clinical course. Treatment options vary depending on age, stage, and grade of cancer, as well as other medical conditions
Aim of study: In this retrospective study we aimed to provide clinico-epidemiological characteristics of prostate cancer and to present different treatment modalities with respect to OS, DFS and PFS
Patients and Methods: Male patients with localized or metastatic prostate cancer presented to Ain Shams University Hospitals in the period from January 2010, to December 2015. In our study, we reviewed medical records of 101 patients including demographic data and clinic-pathological factors were reported, including age, sex, performance status [ECOG], co-morbidities, personal habits, tumor characteristics, surgery, radical treatment, metastatic treatment, treatment response and survival rates were collected
Results: Our population under study had a median age of 69 years [range: 42-85], majority of our patients [94%] had good ECOG performance status [. 2], [44.6%] of the patients were presented to us with metastatic disease, most common symptoms at presentation were prostatism in 72.8% of patients and bony aches in 18.8%. The mean Gleason score among studied population was mean 7.37. 44.6% of the patients were metastatic at time of presentation. Median overall survival in studied population was 31 months, median PFS of the studied group was 17 months and the median DFS 29 months
Conclusion: We provide an overview of patients with prostate cancer in a single tertiary institution in Cairo and it was found that lack of patient awareness in most patients leads to their late presentation at time of diagnosis
RESUMO
Background: the male breast cancer [MBC] is a rare disease and represents less than 1% of all malignancies in men and less than 1% of all breast cancers incident
Aim of study: in this descriptive retrospective study we aimed to provide clinic-epidemiological characteristics of MBC. To present the treatment given with respect to DFS, TTP and OS, to identify possible prognostic factors of the disease and the toxicities encountered by the treatment given
Patients and Method: out of 11313 cancer patients 3046 were breast cancer; 28 of them were MBC. All patients presented to clinical oncology department in Ain Shams University in the period from January 2008 to December 2014 and follow up till December 2016
Results: the median age of patients was 59 years. Around 90% had hormone receptor positive [estrogen and/or progesterone receptors].Two third of the patients had advanced T-stage [T3 and T4]. Infiltrating ductal carcinoma the most common type of histology was encountered. Modified radical mastectomy was the most common [75%] type of surgery done followed by chemotherapy for 21 patients and loco-regional radiotherapy for 20 patients. Tamoxifen was administered in 19 patients. Relapse occurred in 14 patients [50%]. The 5-year disease-free survival [DFS] was 21.4%, the 5-year time to progression [TTP] rate was 21.4% and the 5-year old overall survival [OS] rate was 35.7%
Conclusion: there is always a delay in the male patients since the first complaint until they seek medical advice, which results in an advanced disease at presentation