Is it helicobacter pylori or are they the drugs?

The study included 22 patients of age range 12-76 years. They were selected carefully to have history of drug that induced their gastroduodenal disorders. Biopsy specimens were taken from the gastric antrum of each patient to detect Helicobacter pylori infection by the urease test. Significant association was found between Helicobacter pylori infection and drugs induced gastro duodenal disorders. As the infection was detected in 90.9% of the total patients. Treatment was given to nine H. pylori positive patients which included a single dose of amoxycillin [3gm/week] plus metronidazole [750 mg/day] for a period of two weeks. This regimen was found to be effective in eradicating H. pylori and resulted in disappearance of signs and symptoms in 83.3% of the patients who had gastroduodenal disorder triggered by drugs.

Ciprofloxacin and metronidazol in the treatment of gastroduodenal disorders

The study included 42 patients of age range 16-58 years, were selected randomly from the gastroenterology unit. They were suffering of gastrointestinal disorders and diagnosed as having gastritis, duodenal ulcer or duodenitis. Biopsy specimen was taken from the gastrointestinal lesion from each patient to detect Helicobactor pylori infection by the urease test. Significant association was found between Helicobactor pylori infection and the gastrointestinal disorder being diagnosed, as the infection was detected in 85.7% of the total patients. The infection was detected in 94.1%, 76.4% and 87.5% of the patients having gastritis, duodenal ulcer and duodenitis respectively. A new treatment regimen was tried in this study to eradicate Helicobactor pylori infection. Biopsy specimen was taken from each patient after two weeks of treatment to figure out the effect of therapy on the eradication of Helicobactor pylori. The regimen used included a combination ofciprodar [ciprofloxacin 500 mg. b.i.d.] plus flagyl [metronidazol 200mg. q.i.d.] for two weeks. This regimen was found significantly effective in eradicating Helicobactor pylori and resulted in disappearance of signs and symptoms with the healing of the gastrointestinal lesion. This combination therapy resulted in a healing rate of 81.25%. But there was a difference in response between gastritis, duodenal ulcer and duodenitis. Patients with duodenitis were found to be the most responsive to this regimen. The resultant healing rates were 76.9%, 83.7% and 85.7% for gastritis, duodenal ulcer and duodenitis respectively.

Topical use of phenytoin sodium powder in the healing of post-operative wounds

Efficacy of topical diphenylhydantoin sodium powder in enhancing wound healing and eradicating bacterial contamination was evaluated in 47 patients with different post- operative wounds. Phenytoin sodium powder was applied topically in a dose of 20 mg for each cm[2] daily for 7-14 days until healing process was achieved. Bacterial swabs were taken from wounds before and after application of the pure sterile powder. Culture results were compared with those taken from the control areas. A high significant reduction in wound healing time was achieved after the topical application of the powder to post-operative wounds [8.56 +/- 1.033 days] compared to the control wounds [12.9 +/- 1.635 days]. A direct correlation was found between wound size and healing time. Phenytoin sodium reduced post-operative wound infections to 8.9% compared to 80.9% for control wounds