Evaluation of Efficacy of DAB for Phi Bodies in Acute Leukemia

Diagnosing the type and sub-type of Leukemia is very important as the therapy, prognosis and survival rate changes with each type and sub-type. In the present study French American British (FAB) morphological classification is used and 60 % cases of Leukemia were evaluated by studying the detailed clinical features, morphology on peripheral blood smear and bone marrow aspiration. Out of the 60 cases we found that 40 cases were of acute Leukemia and 20 cases of chronic Leukemia. Out of which 24 were of acute Myeloid Leukemia, 16 of acute Lymphoid Leukemia. There were 15 cases of CML and 5 cases of CLL. Phi bodies appear to be characteristics of immature Myeloid cells in Leukemia and are seen with a higher frequency than Auer rods in acute Myeloid Leukemia

Mucosal malignant melanoma of the nasal cavity.

Mucosal malignant melanoma (MMM) of the nose is extremely rare. We report a case of MMM of the nasal cavity in a 60-year-old male patient presenting with a polypoidal mass in the right nasal cavity. It was increasing gradually and obstructing breathing. A biopsy of the lesion was done with a clinical suspicion of inverted papilloma/carcinoma. Microscopy revealed features suggestive of malignant melanoma with minimal melanin pigmentation. Subsequently wide local excision was done. Diagnosis of malignant melanoma was facilitated by histochemistry and immunohistochemistry.

Filarial granuloma in breast.

A case of filarial granuloma in breast in a 59-year-old female is reported. Adult worm was identified in a breast nodule.