RESUMO
The objective of this study was to explore the role of insulin resistance in women with recurrent spontaneous miscarriage [RSM]. Patients with 3 consecutive spontaneous miscarriages were classified as having RSM. Thirty-five non-pregnant women presenting with RSM in our specialized RSM clinic constituted the study population, while 30 non-pregnant, parous, fertile women without RSM served as controls. The study and control patients were matched for age, ethnicity and body mass index [BMI]. Blood was extracted from these patients for fasting blood glucose and fasting insulin simultaneously, and a battery of investigations including ultrasonography was performed on all the patients with RSM. There was no significant difference in the mean fasting glucose for the study and control patients [5.5 +/- 0.7 vs. 5.3 +/- 0.6 mmol/dl] and in the mean fasting insulin [15.0 +/- 5.1 and 12.9 +/- 2.9 mU/l]. There was a significant difference between the mean parity of the study and control patients [0.7 +/- 0.7 vs. 1.7 +/- 0.5, p < 0.0001] and also the mean number of miscarriages [4.2 +/- 1.2 vs. 0.1 +/- 0.4, p < 0.0001]. There was, however, no significant difference in the insulin resistance of both groups as calculated using the Homeostasis Model Assessment and the fasting glucose insulin ratio of <4.5. Insulin resistance was not significantly associated with RSM in our study. Further studies may be needed