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1.
Oman Medical Journal. 2016; 31 (2): 135-141
em Inglês | IMEMR | ID: emr-176359

RESUMO

Objectives: To study the cytological patterns of fine-needle aspiration cytology [FNAC] obtained from space-occupying lesions [SOLs] of the liver with an aim to differentiate primary hepatocellular carcinoma from metastatic deposits and to evaluate the added advantage and efficacy of studying cell blocks in conjunction with smears for enhancing diagnostic accuracy


Methods: This prospective study took place over two years [September 2007 to 2009] and included 61 patients with cases of liver SOLs that were clinically or radiologically suspicious for malignancy and who were referred for computed tomography or ultrasonography-guided FNAC. Smears were prepared from the aspirated material, and any remainder was used to make the cell block [n = 55]. A final diagnosis was made after evaluating the smears and cell block sections


Results: On cytomorphology, a diagnosis of moderately differentiated hepatocellular carcinoma [HCC] and metastatic carcinoma was made in 10 [18.2%] and 25 [45.5%] cases, respectively, and were confirmed using cell block sections. In cases where it was difficult to differentiate between welldifferentiated HCC and regenerative nodules, and between poorly differentiated HCC and poorly differentiated metastatic carcinoma, a final diagnosis was made with the help of cell blocks sections. Cell blocks assisted in reaching a final diagnosis in 16 [29.1%] cases. Cases that were diagnosed using cytomorphology were confirmed by the cell block method. In these 39 [70.9%] cases we were able to render a diagnosis with much more confidence


Conclusion: In our experience, difficulties in diagnosing SOL liver are attributed to differentiation of the tumor. Cell block preparation gives an additional advantage as architectural details can be studied that help to reach an accurate diagnosis in problematic and challenging cases. Thus, we strongly recommend the use of the cell block technique in conjunction with cytosmears for the purpose of diagnosis


Assuntos
Humanos , Masculino , Feminino , Adulto , Pessoa de Meia-Idade , Idoso , Idoso de 80 Anos ou mais , Biópsia por Agulha Fina , Fígado/patologia , Carcinoma Hepatocelular , Metástase Neoplásica , Estudos Prospectivos
2.
Pan Arab Journal of Neurosurgery. 2011; 15 (1): 71-73
em Inglês | IMEMR | ID: emr-109049

RESUMO

Spinal paragangliomas are neuroendocrine tumours of the extra adrenal paraganglionic system. These tumours are very rare. A case of spinal paraganglioma in an elderly male is reported. A 54-year-old male reported with low backache. Magnetic resonance imaging lumbosacral spine revealed an enhancing intradural lesion at L3 level for which he was operated and histopathology revealed it to be a paraganglioma. Spinal paragangliomas are benign neoplasms and need to be distinguished from more aggressive tumours as their prognosis is excellent

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