RESUMO
Epidermal melanocyte deficit is the basis of Vitiligo. It is a prolonged condition that may be inherited or acquired. Vitiligo affects 1-2 percent of the global population of all races. Several processes have been hypothesized for the breakdown of melanocytes in Vitiligo. These include genetic, autoimmune, oxidative stress, inflammatory mediator production, and melanocyte detachment processes. Vitamin D suppresses UVB-induced apoptosis in keratinocytes and melanocytes by reducing IL-6, IL-8, TNF-a, and TNF-c production. It reduces the autoimmune linked to Vitiligo. We conducted a case-control study in which we compared the level of Vitamin D in patients with Vitiligo and healthy cases. We confirmed our diagnosis with biopsy and utilized the Elisa method to assess the level of Vitamin D. The concentrations of Vitamin D in individuals with Vitiligo were much lower than in controls; however, we did not find a significant effect of vitamin D deficiency on the progression of Vitiligo lesions. Therefore we conclude that Vitamin D is involved in the genesis of Vitiligo, and replenishing the levels may help the patient recover faster.
RESUMO
Background: Epidermoid cysts are cutaneous cysts frequently observed among farmers, factory workers, carpenters, and tailors due to their occupations’ predilection for repetitive minor hand trauma. Case Presentation: A 66-year-old male laborer presented to our hospital with a swelling on the palmar aspect of his right middle finger. The swelling was accompanied by pain and an inability to work over the previous four months. A 2.5 cm × 2.5 cm smooth, tender, immobile, non-compressible hard swelling was detected just above the middle phalanx during the clinical examination on the volar aspect of the right middle finger. The diagnosis was confirmed by histopathology after excision. The patient’s range of motion improved significantly following surgery, and his pain subsided. Conclusion: We present a novel location for an epidermal inclusion cyst and the importance of histopathologic evaluation in this case. Additionally, we emphasize the significance of extensively checking the cyst’s epithelium to guarantee complete capsule removal and rule out any additional pathology.