RESUMO
Rokitansky and Langhans first reported multinucleated giantcells in tuberculous granulomas around a century ago. Inprocess of tissue remodeling and repair the multinucleatedgiant cells (MGCs) acts as inextricable mediators. They alsoaid in removal of various pathogens and foreign materials(Vignery, 2005). Thus, for host survival they have a rolein elimination of foreign substances, damaged tissue, andpathogens. Giant cells are supposed to arise from the monocyteprecursors which forms subsequently to various mechanisms.These cells assume distinctly variable phenotypes dependingupon the mechanism of their formation. This review focuseson the role of the giant cell in oral pathoses such as microbiallesions, cystic lesions, metabolic lesions and cancer.