Chemical Constituents and Biological Activities of Mitrella Kentii (Blume) Miq. Leaf Oil (Komponen Kimia dan Aktiviti Biologi Minyak Daun Mitrella Kentii (Blume) Miq.) / Jurnal Sains Kesihatan Malaysia

@#Chemical constituents and biological activities of the Mitrella kentii leaf oil were investigated in this study. Gas chromatography (GC) and gas chromatography-mass spectrometry (GC-MS) were used to determine the chemical constituents of the oil. The oil was evaluated for its ability to inhibit prostaglandin E2 (PGE2 ) and thromboxane B2 (TXB2 ) productions in human whole blood using a radioimmunoassay technique. Its inhibitory effect on plateletactivating factor (PAF) receptor binding with rabbit platelets using 3 H-PAF as a ligand and its free radical scavenging effect on DPPH were also investigated. Caryophyllene oxide (33.8%w/w), E,Z-farnesol (6.9%), benzyl benzoate (6.5%w/w) and viridiflorol (6.5%w/w) were among the major components of the oil. Even though weak inhibitory activities were observed in both PGE2 and TXB2 assays, significant results were obtained in both PAF receptor binding inhibition and 2,2-diphenyl-1-picrylhydrazyl (DPPH) scavenging effect with IC50 value of 6.6 µg/mL and 155.6 µg/mL respectively. These promising activities warrant the development of the oil as an anti-inflammatory agent.

Knowledge, Awareness and Attitude Related to Hypertension and Garlic Supplement in an Urban Population (Pengetahuan Kesedaran dan Sikap Berkaitan dengan Hipertensi dan Supplemen Bawang Putih di Kalangan Penduduk Bandar) / Jurnal Sains Kesihatan Malaysia

@#Garlic has gained popularity worldwide as a non-pharmacological treatment for hypertension but its use in Malaysia is still moderate. This study was undertaken among Malaysian urban population to assess their knowledge, awareness and attitude towards garlic supplement. This study is a cross sectional study and was carried out from February to May 2015. A total of 202 respondents took part in the study with 45% (n=91) taking garlic supplement. The result demonstrated that there was a significant negative correlation with age and knowledge score (r=-0.15, p=0.03). Majority of the respondents were unaware (n=61/202, 69.8%) that garlic has blood pressure lowering properties. Most preferred conventional medicines (n=119/202, 58.9%) over garlic supplement (n=83/202, 41.1%). However, most of the respondents (n=176/202, 87.1%) were interested to know more about the use of garlic for hypertension. There is no significant correlation between knowledge, awareness and attitude of respondents towards garlic supplement.