RESUMO
To identify the causative drugs of fixed drug eruption, and to assess drug-related body site distribution of fixed drug eruption. This study was conducted at Prince Rashid Hospital and Queen Alia Hospital during the period between January 2008 and June 2009. A total of 64 patients who attended the dermatology clinic with fixed drug eruption were asked about the offending drug. Trimethoprim-sulphamethoxazole was the causative agent in 43 cases [70.3%], followed by Furosemide in 5 cases [7.8%], and Tetracyclines in 4 cases [6,3%]. Other causative drugs included Diclofenac sodium 3 [4.7%], Ciprofloxacin 3 [4.7%], Ibuprofen 2 [3.1%], Metronidazole 2 [3.1%], Norfloxacin 1 [1.6%], and aspirin 1 [1.6%]. The glans penis of the male genitalia was the most commonly involved site [58.0%], followed by the extremities [39.0%], the trunk [20.3%], and the lips [6.3%]. The female genitalia [clitoris] was involved only in two patients [3.1%]. Only one patient [1.6%] developed a generalized bullous drug reaction. Our study highlighted the common occurrence of FDEs, and the range of causative drugs. They were most commonly encountered with trimethoprim-sulphamethoxazole, but quinolones were increasingly seen as causative agents for FDEs. Our study also showed that FDE usually presented as solitary lesion, and in terms of body site distribution the genitalia [mainly the glans penis] was the most frequently involved site