RESUMO
The present investigation was carried to study the influence of myrobalan, myrrh and hop on food intake, body weight, blood glucose, lipid profiles, kidney and liver function and histological characteries of liver and heart of rats suffering from liver diseases. The experiment included [30] male albino rats [Sprague Dawley strain], weighting 150 +/- l0g, [5] of rats fed on basal diet only as control negative group. The second main group [25] rats was treated by subcutaneous injection with CCL4 in paraffin oil [50% V/V 2ml/Kg] twice a week to induce chronic damage in liver. Then divided in five [5] groups as the following: Group 1 control positive, group 2 [G2] fed on basal diet with 10% myrobalan, G3 fed on basal diet with 10% myrrh, G4 fed on basal diet with 10% hop and G5fed on basal diet with 10% herbs mixture. After rats fed for 4 weeks, body weight gain and food efficiency ratio were recorded, and serum glucose, serum lipid parameters and liver and kidney functions measured in serum. Results showed that rats fed on 10% myrrh had significantly decreased [P<0.01] liver weight and serum glucose, compared with [C+]. Also the same rats group had higher HDL-c and lower LDL-c and VLDL-c compared with [C+], the activity of serum AST, ALT and ALP [liver function indication] decreased for different rat groups. This study recommended the consumption of these herbs to improve and treatment of chronic liver disease