Evaluation of subacute toxicity of a polyherbal nootropic formulation in Wistar albino rats

In ayurvedic system of traditional medicine, 'medhyarasayanas' — decoction of selected plants are used to improve intellect or cognition abilities. Here, we investigated one such polyherbal formulation (PHF) with ingredients Bacopa monniera, Glycyrrhiza glabra, Valeriana wallechii and Withania somnifera used as a facilitator of learning, retention and recall. We evaluated the safety of this PHF in animal models. We performed acute oral toxicity test using 2000 mg/kg of the formulation as per OECD guideline 423 and observed for toxicity over 14 days. Thereafter, we divided them into four groups of six animals each and administered Normal saline 5 mL/kg, The PHF (Wilmer®) @500, 1000 and 2000 mg/kg in the respective groups over 28 days. We observed no mortality or physical and behavioural abnormalities in both acute and subacute toxicity study. On the 28th day, animals were sacrificed, blood collected for estimation of haematological and biochemical parameters and histopathological examination of organs was performed. There was significant difference (P <0.05) in Mean ± SEM values of haemoglobin, total cholesterol, total protein, ALT, AST, ALP and serum creatinine in the test groups compared to control as analysed by One-way ANOVA followed by Tukey’s multiple comparison test. We observed steatosis and ballooning of hepatocytes, lymphocytic periglomerular infiltrate, eosinophilic hyaline casts and renal tubular coagulation necrosis in histopathology of test groups. Haematologic abnormalities (decrease in haemoglobin concentration), hepatotoxic, nephrotoxic and dyslipidemic effects of the tested PHF were seen in the rats in subacute toxicity study over 28 days, which could be due to the individual plant products, microbial contamination or heavy metals in the formulation in excess of regulatory limits. Hence, it needs further safety evaluation in animals and humans.

Hepatitis B Virus and Behavioural Risk among Blood Donors, Gabon

Background: In resource-limited setting, co-infection between HIV and hepatitis B virus (HBV) poses important public health considerations. This cross-sectional study was undertaken with the aim of determining HBV seroprevalence patterns in urban blood banks.Methods: A cross-sectional study was conducted at an urban blood bank setting. A total of 1610 blood donors were enrolled, and 283 consecutive plasma samples with unknown HBsAg status were selected for risks factors. HBV seroprevalence was based on the Chemiluminescence method (Cobas® e601, Roche). Potential risk factors associated with overt HBV infection were assessed by calculating the crude and adjusted odds ratio, 95% confidence intervalley (95% CI) and p values.Results: Of 1610 participants, overall rate seroprevalence of HBsAg was 5.5% (95% CI: 4.36%–6.58%) ranging from 0.06% (95% CI: 0-0.18) (HCV) to 0.12% (95% CI: 0-0.30)(Syphilis). Seroprevalence of infection increased in older age groups (20-39 years) but men had a statistically significant higher prevalence of overt HBV infection than women (P=0.0001). The multivariate model showed the following to be predictors of HBV infection: male gender (OR=2.5 (95% CI 1.14-5.58), P= 0.02), first-time donor status (OR = 11.06, (95% CI 5.34-22.9), P= 0.01) andresidence outside of Libreville (OR = 2.52, 95% CI 1.09-5.83), P=0.03).Conclusion: HB and co-infection are n o t common in Gabon. Intermediate seroprevalence was associated with male gender, first-time donor status and residence outside of Libreville. HCV andHBV infection among the younger age groups are becoming an alarming issue. Prevention and control of HBV infection are needed to reduce HBV transmission

Oral mucormycosis in post-COVID-19 patients: A case series

The rise of mucormycosis in COVID-19 patients is predisposed by indiscriminate intake of corticosteroids, poorly controlled diabetes, injury, prolonged neutropenia, organ transplant, hematopoietic malignancies, prolonged stays in the intensive care unit, and due to nosocomial infection. Oral lesions seen in COVID-19 patients are more probably caused by co-infections, adverse reactions, and immunocompromised conditions instead of direct COVID-19 infection. We would like to report a case series of four patients who had oral mucormycosis after the COVID-19 recovery period.

Chemical Profile and Cytotoxicity Activity of Stem-bark of Anacardium occidentale

Column chromatographic fractionation of the methanol and ethyl acetate extracts of the stem-bark of Anacardium occidentale led to the isolation of five compounds (1-5). Their structures were determined by spectroscopic means by comparing spectral data to be β-sitosterol (1), 2,4-dihydroxy acetophenone (2), 1-monolinolein (3), ethyl oleate (4) and β-sitosterol-3-O-β-D-glucopyranoside (5). These compounds were evaluated for cytotoxicity against human cancer cell lines: A549, SCOV3 and rat normal cell line NRK49f.Compounds 2-5 were for the first time isolated from A. occidentale.

Dimensions of pes anserinus of the lower extremity, an anatomical study with its surgical implications / 대한해부학회지

The reconstructive surgeries utilize pes anserinus (PA) tendons, because of their lesser post-operative clinical deficits and donor site morbidity. These surgeries require anatomical knowledge about the extent of PA formation. The goal of this study was to determine the length and width of the PA formation. The objectives were to measure the distance of its upper limit, lower limit, and vertical distance from the tibial tuberosity (TT). The present descriptive cross sectional study included 53 embalmed cadaveric lower extremities. The upper and lower limits of PA were exposed with the careful dissection. Measurements of the dimensions were performed with the help of a digital vernier caliper (Mitutoyo Co., Kanagawa, Japan). The PA length, width, distance of its upper limit, lower limit, and vertical distance of it from the TT were 47.4±13.3 mm, 37.3±7.2 mm, 47.6±12.5 mm, 54.6±10.4 mm, and 39.1±14.2 mm, respectively over the right extremity. The same measurements were 46.3±14.7 mm, 39.1±9.4 mm, 39.1±5.9 mm, 49.5±8.2 mm, and 36.4±12.1 mm, respectively for the left extremity. The extent of PA was observed to be extremely variable. The preoperative knowledge about the dimensions of PA will help the plastic and orthopedic surgeon put the accurate skin incision, decreasing the donor site morbidity and biomechanical instability of the PA grafts. We suggest that, preoperative ultrasound measurement of the PA may help the operating surgeon to prevent the complications like injury to the infrapatellar branch of saphenous nerve.

Dimensions of pes anserinus of the lower extremity, an anatomical study with its surgical implications / 대한해부학회지

The reconstructive surgeries utilize pes anserinus (PA) tendons, because of their lesser post-operative clinical deficits and donor site morbidity. These surgeries require anatomical knowledge about the extent of PA formation. The goal of this study was to determine the length and width of the PA formation. The objectives were to measure the distance of its upper limit, lower limit, and vertical distance from the tibial tuberosity (TT). The present descriptive cross sectional study included 53 embalmed cadaveric lower extremities. The upper and lower limits of PA were exposed with the careful dissection. Measurements of the dimensions were performed with the help of a digital vernier caliper (Mitutoyo Co., Kanagawa, Japan). The PA length, width, distance of its upper limit, lower limit, and vertical distance of it from the TT were 47.4±13.3 mm, 37.3±7.2 mm, 47.6±12.5 mm, 54.6±10.4 mm, and 39.1±14.2 mm, respectively over the right extremity. The same measurements were 46.3±14.7 mm, 39.1±9.4 mm, 39.1±5.9 mm, 49.5±8.2 mm, and 36.4±12.1 mm, respectively for the left extremity. The extent of PA was observed to be extremely variable. The preoperative knowledge about the dimensions of PA will help the plastic and orthopedic surgeon put the accurate skin incision, decreasing the donor site morbidity and biomechanical instability of the PA grafts. We suggest that, preoperative ultrasound measurement of the PA may help the operating surgeon to prevent the complications like injury to the infrapatellar branch of saphenous nerve.

Haemoperitoneum from Spontaneous Rupture of Corpus Luteal Cyst in a Case of Dengue with Thrombocytopenia - A Rare Presentation

Dengue viruses are transmitted to humans by infected mosquitoes, mainly Aedes aegypti and albopictus. Dengue illness is clinically characterized by sudden onset of fever, intense headache, retro orbital pain, myalgia, maculopapular rash, minor bleeding manifestations like petechial rashes, gum bleeding, and severe haemorrhagic manifestations like haematemesis, epistaxis & haemoperitoneum. Haemorrhagic manifestations can occur at any stage. Dengue shock syndrome is a dangerous complication with high mortality.1 Increased vascular permeability together with myocardial dysfunction, dehydration contributes to development of shock resulting in multi-organ failure like liver damage, neurological manifestation & corpus luteal cyst rupture. Endothelial dysfunction induced by cytokines and chemical mediators, results in shock. Corpus luteum is a functional cyst developing in luteal phase of ovarian cycle, which regresses spontaneously to corpus albicans when pregnancy does not occur. Being a thin walled vascular structure corpus luteum is prone to haemorrhage even if bleeding is usually contained inside the cyst. Ruptured functional ovarian cyst is a frequent cause of acute pelvic pain in women of reproductive age. Invariably it is self-limiting with conservative management.2 Occasionally it requires surgical intervention, when accompanied by haemodynamic instability, large haemoperitoneum, especially in disturbed coagulation profile,as in our case.Corpus luteal cyst rupture, with consequent haemoperitoneum is a rare disorder in women of reproductive age. The condition should be promptly diagnosed and treated because delayed diagnosis may significantly reduce women’s fertility and lead to intra-abdominal bleeding, which may be life threatening.3 Ruptured corpus luteal cyst in some instances causes massive intra-peritoneal bleed leading to death, especially with bleeding diathesis.4

Retrospective analysis of intrauterine granulocyte colony-stimulating factor in controlled ovarian stimulation with intrauterine insemination cycle

Background: Persistent thin endometrium affects <1% of patients. Various treatments have been proposed with no satisfactory results. GCSF is one such treatment modality which improves endometrial thickness and implantation. Aim of this study was to analyse the effects of dose and the site of instilling intrauterine G-CSF in COS IUI cycles in patients with unexplained infertility and to note the pregnancy rates among them.Methods: It is a 3-year retrospective study done in obstetrics and gynecology department of AJ Institute of Medical Sciences and Research Centre, that included all unexplained infertility cycles with controlled ovulation stimulation-IUI protocols where for a thin endometrium GCSF was used. The method of ovarian stimulation, the drug and dose used, the trigger for ovulation and the ovarian and endometrial response was noted. The day of the intrauterine GCSF and the dose and the site of instillation was noted. The endometrial response to GCSF the outcome for pregnancy was noted. All the data was analyzed statistically.Results: Significant endometrial response was seen with a dose of 100 mg,150 mg and 300 mg. Pregnancy outcome was better when GCSF was instilled just above the level of the os. GCSF instilled at the level of the fundus increases the possibility of ectopic pregnancy.Conclusions: Instillation of GCSF of 100 mg dosage just above the os; is a safe and effective method for improving the endometrial thickness and increasing pregnancy rate.

Ascertaining the paternal lineage in crossbred calves

Karyotyping is one among the culling parameter used for taking up culling decisions. Cytogenetic screening of breeding bulls has been recommended to screen for chromosomal abnormalities before semen production in artificial insemination. The chromosomal analysis of a Holstein Friesian crossbred bull revealed the presence of acrocentric Y-chromosome, which was further confirmed by CBGbanding. The shape of the Y-chromosome determining that male line used for crossbreeding was from indigenous origin. Karyotyping is a best and reliable technique for the identification of crossbred calves born to the indigenous bulls.

Karyomorphological Studies of Kangayam, Pulikulam, Crossbred Jersey and Crossbred Holstein Friesian Bulls

The present study was carried out in four genetic groups of cattle, viz. Kangayam, Pulikulam, crossbred Jersey and crossbred Holstein Friesian, to compare the karyomorphological pattern between Bos indicus and Bos taurus x indicus bull calves. Metaphase chromosomal spreads obtained by short term lymphocyte culture technique revealed chromosomal complement (2n) of 60, with 29 pairs of autosomes and one pair of sex chromosomes in four groups. All the autosomes were acrocentric, X-chromosome was sub-metacentric and Y-chromosome was acrocentric in Bos indicus and metacentric in crossbred bulls. There was no significant difference in relative length, arm ratio, centromeric index and morphological index of autosomes and X-chromosome between indicine and taurine groups; but Y-chromosome differed significantly (P˂0.01) in relative length between Bos indicus and Bos taurus x indicus crosses. Y-chromosome polymorphism could help in the determination of breed origin and male lines used in the breeding programmes in order to prevent the possible interferences in the process of reproduction

Does full enteral feed from day one of life influence weight gain in hemodynamically stable VLBW babies weighing between 1000-1500 grams as against standard feeding? an open label randomized controlled trial

Background: Preterm neonates post-natal growth should be similar to the intrauterine growth of the fetus of the same gestational age. This study aims to' evaluate the effects of full enteral feed (60 ml/kg/day of human milk on day one, 20ml/kg/day during feeding advancement) started from day one of life (intervention) in enhancing'' the regain of birth weight compared to that of standard feed (both human milk feeds and intravenous fluid) in a group.Methods: Babies were started on enteral feeds with human milk at the rate of 60ml/kg/day from day one and progressed by increments of 20 ml/kg/day up to maximum enteral feed of 180 ml/kg/day. The primary outcomes like Number of days taken to regain the birth weight, Duration of hospital stay, Incidence of Necrotising Enterocolitis (NEC), Incidence of sepsis, need for intravenous fluid therapy was assessed and statically analysed.Results: Full enteral feeding group infants had lesser days of intravenous fluids. Full enteral feeding group regained birth weight at a mean age of 17.37'4.9 days and in the standard feeding group, birth weight was regained at a mean age of 19.8'4.3. Full enteral feeding group regained birth weight at a mean age of 13.12'2.17 days and in standard feeding group at a mean age of 15.38'3.57and this was statistically significant (p - 0.009). Full enteral feeding group babies had lesser number of days of intravenous fluids compared to babies in standard feeding group. It was statistically significant (p - 0.003).Conclusions: Full enteral feeding practices from day one of life with human milk is feasible, cost effective and safe in hemodynamically stable VLBW infants and results in earlier regain of birth weight

Prevalence of hypertension and its risk factors among high school children in Bangalore, India

Background: Hypertension is a prominent health disorder that leads to 12.8% of deaths worldwide. Although predominantly considered a disorder of the adults, the roots of hypertension start from childhood. In the past children usually suffered from secondary hypertension. However, now with increased incidence of obesity, reduced physical activity, unhealthy dietary habits, use of tobacco and alcohol among adolescents there is now an increased prevalence of primary hypertension in this age group. The present study was conducted with the objective of assessing the prevalence of hypertension and its modifiable risk factors in high school children.Methods: The study was conducted among high school students aged 13 to 16 years in urban Bangalore. A self-administered questionnaire was used to assess the lifestyle. Age, sex, height, weight and resting blood pressure were recorded. Odds ratio, Chi square test and logistic regression were used in the analysis.Results: There were 550 students who participated in the study, 300 (54.54%) were males and 250 (45.45%) were females. The prevalence of prehypertension was 21.6% and hypertension was 8.9%. Logistic regression revealed that overweight, obesity, high salt intake, tobacco use, and stress were significantly associated with elevated blood pressure.Conclusions: There is a rise in the prevalence of hypertension among high school students. Changes in lifestyle seem to influence the development of hypertension in this age group. Behaviour change communication should be used to reduce the modifiable risk factors and promote healthy lifestyle among adolescents.

A cross-sectional study on preference of tubectomy over vasectomy among eligible couples in Bengaluru, Karnataka

Background: Population policies, family planning and welfare programmes undertaken by the Government of India, have led to continuous decrease in the fertility rate but sustainability and target of net reproduction rate 1 is not yet achieved. With increase trend of adopting the permanent method of contraception by eligible couples, the preferences of tubectomy over vasectomy is still remarkable. Hence, the present study is taken up to find Knowledge, Attitude and Practice regarding sterilization and factors influencing it.Methods: A cross-sectional study is conducted in the year 2017 among eligible couples who have completed their family size or pregnant women who came for second confinement to Vydehi Institute of Medical Sciences and Research Centre and Shreyas Maternity Home, Hoskote and Shreyas maternity home are included. An institutional ethics committee (IEC) is given on vasectomy, the better method of sterilization and responses are recorded.Results: A total 92.6% couples were aware of permanent family planning methods. Among them only 30.6% couples are aware of vasectomy. There is a significant association between number of children in a family and to undergo sterilization (p=0.02) method. Reason for not choosing vasectomy are unawareness (49.3%) and social stigma (38%) mainly. 11 couples (7.3%) changed their opinion to undergo vasectomy after giving an IEC.Conclusions: Many couples were knowledgeable about tubectomies and opted for it. Only a small number of couples changed their opinion from tubectomy to vasectomy after being given an IEC.

A case of inferior alveolar nerve encircling the arteria maxillaris / 대한해부학회지

Here we report a case of inferior alveolar nerve (IAN), which had variability in its formation. IAN was formed by dual roots, which were branching out from the posterior division of mandibular nerve. The observed roots were forming a loop around the pterygoid part of arteria maxillaris (MA). One of the roots was superficial to the MA and the other was deep to it. It is believed that this type of morphological variation in the formation of IAN can have clinial implications, which include compression by adjacent structures and nerve entrapment. The knowledge of this variation is important to anaesthesiologists and dentists, while administering local anaesthesia. This is also enlightening to the maxillofacial surgeons, neurologists and radiologists.

Physicochemical Properties and Water Quality Parameter of Paddy Soil and Water and Their Relationship With Pesticides Concentration

@#Introduction: Pesticides may influence the physicochemical properties of soil and the water quality parameters, which is vital in maintaining soil fertility and producing high quality crops. Objective: This study aims to determine the relationship between the concentration of pesticides, the physicochemical properties of the paddy soil samples and the water quality parameters of paddy water samples. Methods: A total of 72 soil and 72 water samples were collected in Tanjung Karang, Malaysia. The paddy soil and water were extracted using Quick, Easy, Cheap, Efficient, Rugged and Safe (QuEChERS) and solid phase extraction (SPE) techniques respectively. The concentrations of pesticides were analysed in ultra-high performance liquid chromatography tandem mass spectrometry (UHPLC-MS/MS). The relationship of the concentration of target pesticides and the paddy soil and water physicochemical properties were studied using Spearman correlation. Results: In paddy soil, the concentration of propiconazole shows moderate positive correlation with manganese (Mn) (r = 0.587) (p≤ 0.01). Meanwhile buprofezin-total organic carbon (TOC) (r = -0.55) (p≤ 0.01), imidacloprid-cation exchange capacity (CEC) (r = -0.519) (p≤ 0.01), pymetrozine-sodium (Na) (r = -0.588) (p≤ 0.01), and trifloxystrobin-calcium (Ca) (r = 0.566) (p≤ 0.01) showed moderate negative correlation. Whereas in water, trifloxystrobin showed significant positive correlation with turbidity (r = 0.718) (p≤ 0.01) and tebuconazole showed negative correlation to dissolved oxygen (DO) (r = 0.634) (p≤ 0.01). Conclusion: The presence of pesticides in paddy field may influence the soil and water quality, thus regular monitoring of pesticides usage and nutrient management in soil is deemed important.

Predictors of mortality in COVID-19 patients at Kinshasa University Hospital, Democratic Republic of the Congo (from March to June 2020)

Introduction: since the 1st case of coronavirus disease 2019 (COVID-19) in Kinshasa on March 10th 2020, mortality risk factors have not yet been reported. The objectives of the present study were to assess survival and to identify predictors of mortality in COVID-19 patients at Kinshasa University Hospital.Methods: a retrospective cohort study was conducted, 141 COVID-19 patients admitted at the Kinshasa University Hospital from March 23 to June 15, 2020 were included in the study. Kaplan Meier's method was used to described survival. Predictors of mortality were identified by COX regression models.Results: of the 141 patients admitted with COVID-19, 67.4 % were men (sex ratio 2H:1F); their average age was 49.6±16.5 years. The mortality rate in hospitalized patients with COVID-19 was 29% during the study period with 70% deceased within 24 hours of admission. Survival was decreased with the presence of hypertension, diabetes mellitus, low blood oxygen saturation (BOS), severe or critical stage disease. In multivariate analysis, age between 40 and 59 years [adjusted Hazard Ratio (aHR): 4.07; 95% CI: 1.16 - 8.30], age at least 60 years (aHR: 6.65; 95% CI: 1.48-8.88), severe or critical COVID-19 (aHR: 14.05; 95% CI: 6.3-15.67) and presence of dyspnea (aHR: 5.67; 95% CI: 1.46-21.98) were independently and significantly associated with the risk of death.Conclusion: older age, severe or critical COVID-19 and dyspnea on admission were potential predictors of mortality in patients with COVID-19. These predictors may help clinicians identify patients with a poor prognosis

A cross sectional study to determine the health profile of brick kiln workers

Background: Occupational hazards involving the respiratory system, musculoskeletal system, skin and eyes are very commonly seen in the workers involved in the brick kiln industry. This study was designed to assess health profile of the brick kiln workers and to discuss sociodemographic profile affecting their health.Methods: This was a cross sectional study. 420 workers falling into the eligibility criteria, were selected from the 65 brick kiln factories in the study area. Multi-stage cluster sampling method was used to select the brick kiln factories and the participants of the study. The responses given by the participants were entered in Microsoft Excel 2010 and analyzed using SPSS version 20. Chi Square test was used to determine the association between the morbidities and sociodemographic variables.Results: Mean age of the workers was 35.34±10.96 years. 96.7% of the respondents were suffering from some or the other complaints, while 3.3% were not suffering from any complaints. Addiction was seen in 37.9% of the participants. Musculoskeletal complaints were the most common complaints followed by respiratory and skin complaints.Conclusions: Health of workers is affected due to conditions they work under. The older age group had more respiratory, dermatological and ophthalmic complaints. The group of workers employed as bigaaris as well as those who were working for more than 10 years had more respiratory and dermatological complaints.

Knowledge and awareness of the cause, prevention and control of cervical cancer amongst female undergraduates and faculty of health sciences: a cross sectional survey

Background: Carcinoma cervix is the second most common cancer in women worldwide, and the most common in India. In this study, the current knowledge of female undergraduates and faculty of health sciences regarding the various parameters like risk factors, symptoms, screening tests and vaccinations pertaining to cervical cancer was assessed.Methods: A cross-sectional, self-administered anonymous questionnaire-based survey was carried out, in a medical college in Mangalore, which included 260 staff and students. Non random sampling was done and the study was carried out only after gaining institutional Ethical community approval and written informed consent from the subjects.Results: Majority of the participants 185 (71.4%) were aware that cervical cancer is one of the most wide- spread gynecological cancers in Asia. The awareness of causative agents of cervical cancer was known to 53.9% of the undergraduates and 50% of the faculty members. 73% of the total study groups have heard of HPV and around 68% agreed that it was detectable. 71% of the study sample had heard about the Pap smear test and 42% have undergone the test. The questions pertaining to the preventive measures of cervical cancer had good faculty preponderance with 91.8% giving a positive response. 84.1% of the students and 79.5% of the faculty members knew that abnormal vaginal bleeding was a symptom.Conclusions: In this study an attempt has been made to study the correlates of knowledge of cervical cancer in a cohort which consisted of health care undergraduate and faculty. Majority of our study group was well aware of the various risk factors of cervical cancer and its preventable nature however awareness regarding the association between diets, multiple pregnancies and use of tobacco was poor.

Evaluation of the performance of a nutrition rehabilitation centre in a tertiary care hospital in Eastern India

Background: Severe acute malnutrition (SAM) places extraordinary challenges in the way of survival, growth and development of the child under five years of age. Our aim was to evaluate the functioning and performance of facility based management of SAM children admitted in the nutrition rehabilitation centre (NRC) and to identify the existing bottlenecks in the NRC.Methods: Children above 1 month and less than 5 years of age with severe acute malnutrition were included during the study period. Demographic details of the SAM children, clinical features during admission were recorded. Anthropometric measurements like MUAC, weight, height/length and WHZ scores were taken at admission and compared with the findings at discharge. Statistical analysis: the data after collection, compilation was analysed by SPSS.Results: Majority 277 (78.47%) of them belonged to rural areas. 300 (85%) SAM children were referred by medical officers. Bilateral oedema was recorded in 12 (17.9%) admitted children during 2014-2015, 22 (17.9%) children in 2015-2016 and in 37 (22.7%) children during 2016-2017. There was significant improvement in the mean weight (kg) and mean MUAC (cm) at discharge was in comparison to the weight and MUAC of the children at admission and this difference in increase in the mean weight and MUAC were found to be statistically significant.Conclusions: Implementation of WHO feeding guidelines resulted in adequate weight gain of inpatient malnourished children, however the frontline workers in the community and health care providers of PHCs should be trained and given hands on training for early identification and referral of SAM cases

Feto-Maternal Outcome In Singleton Pregnancies With Polyhydramnios: A Case Control Study.

Objectives - To study the fetal and maternal outcome, in pregnancies complicated by polyhydramnios with that of pregnancies having normal fluid volume. Maternal and Methods This prospective case control study was conducted on 100 patients with polyhydramnios and 100 pregnant women with normal fluid volume over a period of 18 months from April 2017 to September 2018. Results Out of 100 patients with AFI > 24, 12% had congenital anomalies, out of which GIT were maximum as compared to control group only 2%. The most common maternal complication in the study group was preterm labor, malpresentation, PROM, eclampsia, auptio placenta, dyspnea, cord prolapse and atonic PPH, slightly more as compared to study group. Gestational age at delivery in the study group was 37.6 weeks as compared to 38.2 weeks in control group. The study group had more number of labor inductions, LSCS, fetal distress, low 1 and 5 minute Apgar Score, NICU admissions, meconium aspiration, respiratory distress and perinatal deaths as compared to control group. Conclusion Polyhydramnios poses danger for both mother and baby, hence there is a need to have an anomaly scan at an earlier gestation and monthly amniotic fluid assessment from 20th week onward for diagnosis of polyhydramnios and timely intervention so as to reduce the maternal morbidity and perinatal morbidity and mortality.