[ effects of whortleberry on controlling of blood glucose and lipids in patients with type II diabetes: a randomized controlled trial]

Type II diabetes is the most common metabolic disease in the world. The aim of present study wos to determine the effects of whortleberry on glucose control index and lipid profile in patients with type II diabetes. The present study was a randomized trial [IRCT: 1389]. The sample was 75 patients with type II diabetes [30 people in intervention and 45 people in control group] in Karaj-Iran. The control groups took placebo capsules [starch] and whortleberry [500 mg, twice a day after breakfast and lunch] was administered in intervention group. Vein blood samples were taken at the beginning and end of study to measure fasting blood glucose, glycosylated hemoglobin [HbA1c], insulin serum, Triglyceride, total Cholesterol and its contents. Using HOMA Score, insulin resistance was also measured. Descriptive statistics and chi-squared, T- independent, paired T and ANCOVA testes were used for data analysis. After 90 days of the intervention, there was a significant difference in FBS, two hour blood sugar [BS2hpp] and HOMA Score between Whortleberry and control group. Also In whortleberry group, in all glucose control indexes, there were significant differences After 90 days of the intervention. This study demonstrated that using of oral whortleberry supplement for adjusting blood glucose is suitable for patients with type II diabetes patients. Therefore using of it along with medical treatment can be recommended

[Comparison of diagnostic value of fasting plasma glucose with 100 gram oral glucose tolerance test in gestational diabetes mellitus screening]

Many different tests have been introduced for screening of gestational diabetes mellitus [GDM]. The objectives of this study were comparison of diagnostic value of fasting plasma glucose [FPG] with 100 gram oral glucose tolerance test [OGTT] and determining the suitable cut-off point of plasma glucose with best sensitivity and specificity for diagnosis of gestational diabetes mellitus [GDM]. This study was a clinical trial and carried out on 242 women in Kara-Iran. After doing 50 gram glucose challenge test [GCT], if 1- hour plasma glucose was >/= 130 mg/dl, the 3 hours 100 gram OGTT was performed. The diagnostic values of FPG and 1, 2 and 3 hours plasma glucose were compared by receiver operating characteristic curve [ROC]. Overall 50 gram GCT was positive in 41/3%. Then 100 gram OGTT for these was performed, 36% were identified as GDM. With using below surface of ROC curve for FPG [0/75], 1-hour [0/87], 2-hour [0/95] and 3-hour [0/75] plasma glucose determined that FPG with cut-off point >/= 91 mg/dl had 63.89% sensitivity rate and 76/56% specificity rate for diagnosis of GDM. However, 2-hour plasma glucose with cut-off point >/= 153 mg/dl had highest level of sensitivity rate [91/67%] and specificity rate [89/06%]. Two-hour glucose with cut-off point >/= 153 mg/dl had the best sensitivity and specificity rate in diagnosis of GDM. Therefore, 100 gram OGTT recommended for screening of GDM