RESUMO
Objective: The objective of the present study is to evaluate the effect of Phthalate analogues of diclofenac in Freund’s complete adjuvant (FCA) induced Arthritis in the rat. Methods: Twenty four female albino wistar rats were enrolled in this study and are divided into 4 groups (six each). The groups were designed as follows: Group I: vehicle control, Group II: arthritic control, Group III: diclofenac treated, Group IV: phthalate analogue of diclofenac treated. Various assessments such as anti-arthritic activity, biochemical estimations, haematological parameters, ulcerogenesis, radiological and histopathological studies were evaluated. Results: Arthritic control group exhibited significant increase in the level of paw volume, arthritic score (p<0.0001), Serum glutamic pyruvic transaminase (SGPT) (p<0.001), Serum glutamic oxaloacetic transaminase (SGOT) p<0.01), rheumatoid arthritis factor, C-reactive protein (CRP), White Blood Cells (WBC), Creatinine and uric acid and a significant decrease in Red Blood Cells (RBC). Increased swelling of joints, bony destruction and profound ulceration were observed in the Arthritic control group. All these conditions were reversed in diclofenac and phthalate analogue of diclofenac groups. Conclusion: We conclude that phthalate analogue of diclofenac shows potent anti-arthritic activity with milder ulceration when compared to diclofenac treatment.
RESUMO
Background:Although almost 400 blood group antigens have been reported, the ABO and Rh have been recognized as the major clinically significant blood group antigens. Research on ABO group system has been of immense interest, due to its medical importance in different diseases Aim: To study the relationship between type of ABO blood group and incidence of coronary artery disease. Methods: This study was conducted in the Department of Cardiology and Medicine, Government Rajaji Hospital Madurai. Patients admitted with clinical features of acute myocardial infarction confirmed by ECG and patients admitted with angina pectoris clinically were included. Detailed history, general examination, cardiovascular examination and relevant investigations were done in all patients. Results: Incidence of coronary Artery disease is predominant in ‘A’ group. Incidence of Arrhythmias are more in ‘A’ group. Complications like LV clot and LV dysfunction do not have relationship with blood group. Conclusion: Type of ABO blood group seems to have an impact onthe risk of coronary artery involvement and the type of blood group effects on severity of CAD. Incidence of coronary Artery disease is predominant in ‘A’ group.