RESUMO
Statins, as the first-line anti-atherosclerosis drugs, are of significant benefit in reducing the risk for cardiovascular and cerebrovascular events. However, many studies have shown that the patient adherence to statin is poor in clinical practice, and many cardiovascular patients abruptly discontinue therapy. Acute withdrawal of statin therapy may have a rebound effect on patient outcomes, and clinicians should pay attention to statin withdrawal syndrome to avoid its occurence.
RESUMO
Statins, as the first-line anti-atherosclerosis drugs, are of significant benefit in reducing the risk for cardiovascular and cerebrovascular events. However, many studies have shown that the patient adherence to statin is poor in clinical practice, and many cardiovascular patients abruptly discontinue therapy. Acute withdrawal of statin therapy may have a rebound effect on patient outcomes, and clinicians should pay attention to statin withdrawal syndrome to avoid its occurence.
RESUMO
Objective To determine the influencing factors on informed consent associated with decline or delay of primary percutaneous coronary intervention (PCI) in patients with acute ST-segment elevation myocardial infarction(STEMI).Methods This study was conducted in Peking University People′s Hospital from 1 August, 2014 to 31 March, 2016, with 229 consecutive cases of acute STEMI enrolled in the study.Data were collected by reviewing medical records and STEMI treatment time records.180 patients with ischemic symptoms ≤12 hours were included in the final analysis.Patients were divided into the consent group and the refusal group according to the final decision.For patients who received primary PCI, they were further categorized into two groups based on the 30min cut-off time.Results Among the 180 STEMI patients reviewed, 139 patients agreed to primary PCI and the remaining 41 patients refused primary PCI.Multivariate logistic analysis showed that symptom relief (OR 5.532, 95% CI 1.165-26.278, P=0.031) and history of chronic kidney disease (OR 4.786, 95% CI 1.346-17.011, P=0.016) were predictors of dissent of primary PCI.Self-rated symptoms severity (OR 0.094, 95% CI 0.034-0.260, P<0.001)was predictor of consent to primary PCI.106 patients had complete time point records of informed consent in the consent group (n=139).Among these patients, the median informed consent delay was 24 min.64 patients made a decision within 30 minutes, and the other 42 patients had their decision made beyond 30 minutes.Symptom-to-door time ≥4 hours (OR 4.563,95% CI 1.682-12.385, P=0.003) was independent predictor of informed consent delay.Conclusions Patients with resolved symptoms, self-rated mild symptoms or renal insufficiency were more inclined to refuse primary PCI.For patients who eventually received primary PCI, symptom-to-door time ≥4 hours was the independent predictor of informed consent delay.