RESUMO
To evaluate the effect of high dose thiamine on postprandial blood glucose [PPBG] and hemoglobin A 1C levels in induced diabetic albino rat model. Experimental/Analytical study. Animal House, Isra University Hyderabad from March to October 2013. Forty adult albino rats were divided into four groups; Group I. Controls receiving normal diet, Group II. Controls receiving thiamine fortified diet, Group III. Diabetics receiving normal diet and Group IV. Diabetics receiving thiamine fortified diet. Diabetes mellitus was induced using Streptozocin. Thiamine was given at a dose of 1.6 g/kg body weight. Venous blood samples were drawn from animal's tail with a small bore cannula before and after 12 weeks of experimentation. The PPBG levels and Glycosylated HbA [HbA1c] were measured. The data was converted into database and analyzed on SPSS version 21.0 by ANOVA and Tukey-Kramer's test. A p-value of
RESUMO
To investigate the protective effect of Pentoxifylline [PTX] in carbon tetrachloride [CC1[4]] induced liver injury in adult male Wistar rat model. Experimental/Analytical study. Animal House, Isra University Hyderabad from May to December 2012. Forty five adult male Wistar rats were divided into three groups; Group A. controls received 0.9% isotonic saline, Group B. received CC1[4] orally [I.9mg/kg] mixed in olive oil, and Group C. received the PTX+ CC1[4]. Blood samples were collected for liver biochemical assays. The animals were sacrificed, liver tissue, after fixation in 4% formaldehyde, was embedded in paraffin. Tissue sections of 5micro thickness were subjected to haematoxylin and eosin staining and were assessed by light microscopy. The data was analyzed on SPSS 21.0 using one-way ANOVA, Tukey-Cramer and Chi-square tests. A p-value of