Insulin-like growth factor- 1 in the pathogenesis of ostesarthitis

The destructive process of the articular cartilage in osteoarthritis has a complex pathogenesis. Although the view was originally held that only cartilage loss occurs in osteoarthritis, it has been shown that cartilage metabolism is also increased, leading to increased synthesis of proteoglycans and collagen. This increased anabolic activity is seen as an attempt to repair the cartilage damage and might slow net cartilage loss. It is therefore of interest to study the factors that stimulate cartilage synthesis. One of these could be insulin-like growth factor-1. Recent experimental and clinical studies provide evidence for the pathogenic role of insulin-related growth factor-1

Phonophoresis with voltaren emuldel in the complex treatment of patients with rotator cuff tendinitis

The potential benefit of phonophoresis with Voltaren emulgel was investigated in 72 consecutive patients with rotator cuff tendinitis, using a controlled study design. The patients received complex physical treatment, including hot pack applications, exercises plus phonophoresis with Voltaren gel in one group and plain ultrasound therapy in an other group. The treatment modalities used for phonophoresis are based on previous reports of the transmission characteristics of topical non-steroidal anti-inflammatory products. After 12 sessions of physical therapy, significant improvement was found in pain reduction and range of shoulder movements, suggesting better therapeutic results from phonophoresis with voltaren emulgel compared to ultrasound therapy