Genetic study of anti-microbial drug resistance strains of pseudomonas aeruginosa

The present work was carried out to study the genetic factors for multi-drug resistance in clinically isolated strains of Ps. aeruginosa. Conjugal transfer of resistance factor between Ps. aeruginosa strains was observed, while no transfer was found from Ps. aeruginosa to E. coli strains. The DNA analysis by gel-ectrophoresis revealed the presence of plasmid in one strain [AQ 003] only. As no conjugal transfer or presence of plasmid was observed in other strains, it is suggested that in these strains resistance may be of chromosomal or genetic origin