RESUMO
Tuftsin, a naturally occurring tetrapeptide with a sequence Thr-Lys-Pro-Arg was evaluated for its in vivo protective effect against cyclophosphamide-induced genotoxicity and oxidative stress in Swiss albino mice. The anticancer drug cyclophosphamide (CP) was administered intra-peritonially to induce mutagenic effect. The drug treatment caused significant increase in chromosomal aberrations, formation of micronucleated polychromatic erythrocytes (MNPCE's), as well as oxidative stress and decrease in lipid peroxidation in liver of the animals. The pretreatment with tuftsin abolished such effects in dose-dependent manner and also increased mitotic index in the experimental animals. Results of the present study validated chemo-preventive properties of tuftsin against CP-induced chromosomal mutations and cellular injury of liver by oxidative stress.
Assuntos
Animais , Antioxidantes/administração & dosagem , Antioxidantes/farmacologia , Aberrações Cromossômicas/induzido quimicamente , Aberrações Cromossômicas/efeitos dos fármacos , Ciclofosfamida , Dano ao DNA/efeitos dos fármacos , Relação Dose-Resposta a Droga , Eritrócitos/efeitos dos fármacos , Eritrócitos/patologia , Feminino , Peroxidação de Lipídeos/efeitos dos fármacos , Lipossomos , Fígado/efeitos dos fármacos , Fígado/fisiopatologia , Camundongos , Testes para Micronúcleos , Mitose/efeitos dos fármacos , Estresse Oxidativo/efeitos dos fármacos , Distribuição Aleatória , Tuftsina/administração & dosagemRESUMO
Midfacial degloving is a well known technique for entering the nasal and paranasal cavities, the nasopharynx and the base of skull. We report our experience with midfacial degloving approach, applied to two patients with Juvenile Angiofibroma of nasal cavity and nasopharynx. We have found this approach ideal for access to the nasopharynx and infratemporal fossa while avoiding an external skin incision. The long term cosmetic results are excellent along with complete excision of the tumour
Assuntos
Humanos , Masculino , Neoplasias Nasofaríngeas/cirurgiaRESUMO
The term lateral rhinotomy literally means, to make an openings in the lateral wall of nose. The versatility of the approach can be appreciated by the fact that by simple modifications a variety of procedures can be performed on the nasal cavity, paranasal sinuses and nasopharynx Lateral rhinotomy is an approach and not an operation. It gives very good exposeure of nasal cavity and access to paranasal sinuses and nasopharynx The incision can be modified and extended to the need. We recommend that the lower end of the incision should be brought just below the mid point of vestibule and extended into the nose or upto the columella and upper lip after opening of the lateral wall of nose and confirming the extent of the disease as required