RESUMO
Traditional medicine covers the rescue of the methodologies and techniques of cure, therapy, and prevention of diseases using medicinal plants. The objective of this paper is to conduct a literature review on the use of herbal medicines in skin treatment. The methodology used was a literature review conducted between 2015 and 2022 in national journals. The databases used were Google Scholar, SciELO, VHL, PubMed, and LILACS, using the following descriptors: "use of herbal medicines in skin treatments", "herbal medicines in skin treatments" and, "phytotherapy". The most commonly used medicinal plants were babosas (Aloe vera L.), arnica (Arnica acaulis L.), and barbatimão (Stryphnodendron adstringens (Mart.) Coville), confrei (Symphytum officinale L.), calendula (Calendula arvensis L.) and melaleuca (Melaleuca alternifolia L.). The most commonly used parts were leaves and bark, and infusion (tea) was the most commonly used preparation method. Most of the medicinal plants cited have their healing power evidenced by the scientific literature, thus favoring the quality of life of the individual who uses them. Thus, this article, obtained expressive results for human health, moreover, they establish an important step of bioprospecting, assisting in the choice of target plants for pharmacological verifications.
RESUMO
Background: Coronary artery disease (CAD) is a multifactorial disease whose etiogenesis involves a number of environmental, genetic and lifestyle-related factors. Genetic polymorphisms are noteworthy among these factors because they alter gene expression and, thus, the functions of the respective products. Methods: A case-control study was conducted in the Cardiology Institute, with 79 subjects classified as cases with CAD, and 96 subjects as controls without CAD or other disease. In this study, we evaluated the association between the single-nucleotide polymorphisms (SNPs) of S447X and Leu7Pro of the lipoprotein lipase (LPL) and neuropeptide Y (NPY) genes, respectively. Results: No differences were found in the frequencies of LPL SNP between the cases and controls. However, the LPL 447X allele carriers exhibited a near-significant difference in the triglycerides (p=0.086) and higher mean in the HDL-c (p=0.018). NPY polymorphisms proved to be infrequent in this study population, and no significant difference was observed between the groups. Conclusions: Our findings provide further support of the genetic polymorphisms effect on the lipid metabolism control. So, further studies are needed to assess the functional effect of this and other polymorphisms, on LPL and in the NPY activity, and their impact on CAD risk.