RESUMO
Objective: To evaluate the survival rate of patients with advanced prostate cancer in a univariate form, according to the preoperative and first postoperative determination of PSA levels. Materials and Methods: From February 1987 to June 1995, 92 patients were submitted to maximum blockage androgen (subcapsular and antiadrogen orchiectomy), independent of clinical symptons shown upon admission to the Cancer Hospital. The antiandrogens (ciproterone acetate and flutamide) were administered until the patient present progression of the disease. Results: The age of patients varied from 44 to 89, with a median of 70 years old. In the 6th, 36th and 60th months the global survival rate was 80 percent, 38 per cent and 20 per cent, respectively. The preoperative PSA ranged from 2 to 4017 ng/ml, with a median of 98 ng/ml (98 per cent had PSA greater than or equal to 10 ng/ml). The first postoperative PSA ranged from 1 to 3840 ng/ml, with a median of 20 ng/ml. There was a tendency towards a better survival rate only in patients with initial PSA from 2 to 99 ng/ml (p=0.06745). The survival rate of patients at 36 months after initial total blockage androgen, with first PSA level from 1 to 4, 5 to 49 and over 49 ng/ml was 72 per cent, 48 per cent and 8 per cent, respectively (p=0.00004). In the final examination, 34 (37 per cent) patients were considered stable and 58 (63 per cent) had disease progression. Conlusion: The PSA determination performed on the 30th postoperative day is important in the evaluation of advanced prostate cancer prognosis.
Assuntos
Adulto , Pessoa de Meia-Idade , Humanos , Masculino , Neoplasias da Próstata/sangue , Antígeno Prostático Específico/sangue , Acetato de Ciproterona/uso terapêutico , Flutamida/uso terapêutico , Antagonistas de Androgênios/uso terapêutico , Período Pós-Operatório , Prognóstico , Neoplasias da Próstata/mortalidade , Neoplasias da Próstata/tratamento farmacológico , Índice de Gravidade de Doença , Idoso de 80 Anos ou mais , Cuidados Pré-Operatórios , Orquiectomia , Taxa de Sobrevida , Estudos RetrospectivosRESUMO
Os autores relatam caso de uma paciente de 24 anos, sexo feminino, portadora de carcinoma de glândulas sudoríparas em região axilar esquerda. Uma revisão da literatura demonstra a extrema raridade desta neoplasia. São apresentadas história clínica, evolução, ducumentação histopatológica assim como avaliação imuno-histoquímica.