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Rev. méd. Chile ; 128(4): 437-46, abr. 2000. ilus, graf
Artigo em Espanhol | LILACS | ID: lil-263715

RESUMO

PPARs are transcription factors belonging to the super family of hormonal receptors. Their activity is regulated by fibrates, thiazolidinediones, certain anti inflammatory drugs and fatty acid derivatives, present in food. PPAR isoforms play a central role in lipid homeostasis, regulating anabolic (PPARg) and catabolic (PPARa) pathways of lipid metabolism. Additionally, these receptors participate in glucose homeostasis, influence cellular proliferation and differentiation and participate in inflammatory processes. The effects of PPARs on oxidative substrate partitioning suggests that they have a relevant role in the development of obesity and insulin resistance


Assuntos
Humanos , Proliferadores de Peroxissomos/metabolismo , Diabetes Mellitus/metabolismo , Obesidade/metabolismo , Peroxidação de Lipídeos/fisiologia , Lipídeos/metabolismo
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