RESUMO
Colorectal cancer is the second leading cause of cancer death worldwide. Through risk assessment of malignancy in polyps, screening programs can achieve the best results. This study aimed to determine the association between the grade of dysplasia and the location of colorectal polyps. 240 colorectal adenomatous polyps which were referred to department of pathology at Rasoul-e-Akram Hospital between 2005 and 2009 met the inclusion criteria. Demographic data and information about size of polyps, grade of dysplasia and location of polyps were collected and analyzed by Chi-square and t-test. 124 [58.8%] patients were male and 87 [41.2%] were female. The mean age of the patients was 61.6 years. 47 [19.6%] polyps were right-sided and 193 [80.4%] were left sided. 39 [16.2%] polyps had high grade dysplasia. 27 [12.8%] patients had 56 synchronous polyps [23.3%]. 176 [73.3%], 39 [16.2%] and 25 [10.5%] polyps were of tubular, tubulovillous and villous types respectively. The greatest dimension of 110 [45.8%] polyps was <0.5 cm, 97 [40.4%] 0.5-1 cm, 22 [9.2%] between 1 and 2 cm and finally 11 [4.6%] >2 cm. High grade dysplasia was detected in 3 [6.3%] of right-sided and 36 [18.6%] of left-sided polyps. The obtained results revealed that size of polyp and amount of villous component were strongly associated with high grade dysplasia. Left side location of polyps was independently associated with high grade dysplasia. Left-sided colorectal polyps must be treated more seriously, especially the larger ones with villous component. There was no association between age and gender and the grade of dysplasia
RESUMO
Myocardial infarction is the major cause of morbidity and mortality in industrialized countries. Platelet count and the mean platelet volume [MPV], a simple and reliable indicator of platelet size which correlates with platelet activation, might associate with troponin in acute chest pain. We analyzed MPV of 851 patients who were admitted to Rasoul-e-Akram Hospital with acute chest pain during the year 2010. Two blood samples were taken from each patient within 4 hours of their arrival for routine hematology, including platelet count and MPV, and cardiac troponin T. Also, electrocardiograms of the patients were recorded. Association of MPV and platelet count with troponin was observed. The patients in troponin positive group, who had also ischemic electrocardiographic changes, had higher MPV values than non- acute coronary syndrome [ACS] patients with normal cardiac troponin T levels [9.9 vs 9.5 fl with p< 0.001]. In troponin negative group, the mean of platelet count was higher than that in the positive group [221683 vs 198814/micro l with p< 0.001]. MPV and platelet count are inexpensive laboratory tests which can be measured in association with other laboratory biomarkers in patients presenting with acute chest pain. This could help to lower hospitalization rates and also avoid misdiagnosis and having complications of patients with ACS