RESUMO
Background: Endometrial receptivity plays a key role in the establishment of successful implantation and its impairment may contribute to subfertility and limit the assisted reproduction techniques [ART] success
Objective: The aim of present study was to investigate endometrial receptivity in terms of beta3 integrin, calcitonin and plexin-B1 expression in women with unexplained infertility
Materials and Methods: We evaluated expression of beta3 integrin, calcitonin and plexin-B1 through mRNA level measurement with real-time RT-PCR, in the endometrium of 16 infertile patients with unexplained infertility and 10 fertile women. Endometrial biopsies were collected during a single menstrual cycle on postovulatory day LH+7 in each subject
Results: Significant differences regarding beta3 integrin and calcitonin expression levels found between patients with unexplained infertility and the fertile women. Endometrial plexin-B1 expression levels showed no significant difference between fertile and infertile women. There were significant correlations between expression of beta3 integrin with calcitonin and plexin-B1 in fertile and infertile women
Conclusion: Reduced in endometrial expression of beta3 integrin and calcitonin alone or together may contribute to unexplained infertility and these genes could account as the potential molecular markers of infertility