RESUMO
Research and planning to improve the quality of life for elderly seems to be essential, as the population of this age group has shown an increasing trend. Any chronic disease including diabetes has an impact on lifestyle of the patient. The objective of this study was to compare the quality of life between two groups of elderly diabetic patients who were residence of home as well as nursing home. A descriptive analytical random study was conducted during 2010-2011 on two groups of 93 elderly diabetic patients, who were living in Kahrizak nursing home of Tehran [Iran], and home residents as well by interview for their demographical information and one standard questionnaire provided by world health organization. SPSS 16 was employed for data analysis. Significant differences were found in physical, psychological and social domains between two groups [P<0.05]. In physical and social domains the elderly diabetic patients of nursing home had a higher mean score but in psychological domain the result was in contrast. Regarding the difference between scores in two studied groups it is necessary to study the weak points of each group individually and try to resolve the problems
RESUMO
The methylenetetrahydrofolate reductase [MTHFR] gene polymorphism C677T is suspected to be a risk factor for psychiatric disorders, but it remains inconclusive whether the MTHFR polymorphism C677T is imputed to vulnerability to schizophrenia and bipolar disorder. We prompted impetus to appraise this polymorphism in an Iranian population. Therefore, 90 patients with bipolar disorder type I [BID], 66 patients with schizophrenia diagnosed according to DSM-IV criteria, and 94 unrelated controls with no history of psychiatric disorders were recruited for this study. Genotype distribution and allelic frequencies of C677T polymorphism were investigated. We found no robust differences between patients with BID and schizophrenia with control participants either for allele frequencies or genotype distribution of MTHFR C677T polymorphism. However, a trend toward an increased risk for T allele was observed in the BID patients [with odds ratio [OR] of 1.28[CI 95%: 0.8-1.31], p>0.05]. However, the present and some previous studies failed to elucidate possible interaction between MTHFR C677T polymorphism and vulnerability to schizophrenia and bipolar disorder; still some associations have been revealed in performed meta-analyses that warrant further studies