RESUMO
Objective: Diabetes is a common metabolic disorder that a one of the important factors in the etiology is considered to oxidative damage. The present study intends to study the effect of swimming training with Arbutin on total oxidant status [TOS] and total antioxidant status [TAS] in kidney tissue of Alloxan-induced diabetic rats
Methods: We randomly divided 42 male Wistar rats that had an average weight of 195 g to 220 g into 6 groups [7 rats per group] - control, diabetic, arbutin, diabetic-arbutin, diabetic-swimming training, and diabetic-combinatorial. Swimming training protocol consisted of 5 days/week for 6 weeks at 5-36 min/day. Diabetes was induced with alloxan [90 mg/kg, intraperitoneal [ip]] in the rats. Arbutin [50 mg/kg, subcutaneous] was administered for 5 days/week. The rats were killed 48 hours after the last treatments and kidney TOS and TAS levels were evaluated. One-way analysis of variance was used for data analysis
Results: After six weeks of supplementation with arbutin, swimming training and the combination of swimming training and arbutin, we observed a significant decrease in TOS [P<0.05] and elevated TAS [P<0.05] levels in the alloxan-induced diabetic rats
Conclusion: The combined effect of swimming training and arbutin supplementation can play a major role against renal oxidative stress by modulating total oxidant and antioxidant status in alloxan-induced diabetic rats
RESUMO
Methods of lifestyle modification, including exercise can prevent cardiovascular disease in hypertensive patients through augmentation of endothelial function. The aim of this study was to determine the effect of 6 weeks of aerobic exercise on the plasma levels of vascular endothelial growth factor [VEGF] and glucose in hypertensive postmenopausal women. In this clinical trial, 20 stage 1 hypertensive postmenopausal women [50-55 years old] were randomly divided into two groups of exercise training and control. Training program consisted of 6 weeks of 45-60min aerobic exercise at 50-65% of maximum heart rate, for 45-60min persession, and 3 sessions per week. The control group did not participate in any training program. Blood pressure [BP] and plasma levels of VEGF and glucose was measured before and 48h after the last training session. Data were analyzed using Kolmogorov-Smirnov, levene, and paired t-tests. p<0.05 was considered statistically significant. Systolic and diastolic BP was significantly reduced in the exercise training group after 6 weeks [p<0.001]. In addition, 6 weeks of aerobic exercise significantly increased VEGF [p<0.002] and decreased glucose level [p<0.001]. According to the results of this study, regular aerobic exercise training is associated with a decrease in blood glucose and also an increase in VEFG in hypertensive postmenopausal women