Effect of topical application of nano retinol on mild to moderate acne vulgaris

Background: acne vulgaris is a common skin condition with substantial cutaneous and psychologic disease burden. Estimates of acne prevalence vary substantially given the absence of a universally accepted or grading schema

Aim of the Work: the aim of work is to assess the efficacy and tolerability of topical application of Nano retinol in the treatment of mild to moderate facial acne vulgaris in comparison to classic retinoids

Patients and Methods: this study was conducted as a prospective, split face comparative clinical study on 30 female patients participated for treatment of facial acne vulgaris. All patients recruited from outpatient clinic of dermatology department, Ain Shams University in the period from November 2015 to December 2016.History and clinical examinations were done for each patient

Results: reduction in the total and inflammatory acne lesion count were reported to be significantly greater in the nano formulation as compared to the conventional formulation .local adverse events were significantly less in the nano formulation as compared to the conventional formulation

Conclusion: nanosomal retinol with iontophoresis is more effective and better toletated than its convential formulation with nearly no side effects and no precautions for use

Recommendations: more studies are needed on a wider scale, greater number of patients with different grades of acne vulgaris to support our findings

Comparison of sensitivity and specificity of DWIBS and contrast enhanced T1Wi sequences in characterization of suspicious mammography lesions

Background: diffusion Weighted Imaging with Back-ground Suppression is a new technique which uses the same concept of diffusion weighted imaging yet has the privilege of back-ground suppression and acquisition at a wider range of b-values hence increasing sensitivity and specificity

Objective: to determine the accuracy of DWIBS MR imaging in comparison to the DEC MR imaging in characterizing suspicious mammography lesions

Patients and Methods: twenty patients were included in the study, all with suspicious breast lesions from Ain-Shams University mammography clinic. A cross-sectional study was held where all the patients under-went MRI breast protocol which included DCE and DWIBS sequences. The MRI of all the patients was read by two expert radiologists blinded to each other's opinion. Biopsy was then done for histo-pathological correlation. The results were statistically analyzed

Results: seventy percent of the patients included in our study had malignant lesions and 30% had benign lesions. Both DWIBS and DCE showed comparable efficacy of 90% and 95% respectively

Conclusion: DWIBS can be used as an adjunct to DCE breast MRI improving its sensitivity and specificity. It can as well be used instead of DCE sequences in cases of renal impairment

Skin manifestations in insulin dependent diabetes mellitus [IDDM]

This study included one hundred children with IDDM, 51 females and 49 males with mean age 9.15 years +/- 2.25. They were subjected to full history taking, thorough clinical examination and investigations including random urine sugar and acetone, random blood sugar, glycosylated hemoglobin level, and clinical examination of skin lesions. Bacteriological and mycological examinations were done when needed. No significant relation was detected between the occurrence of skin manifestations and either the blood glucose level or the presence of ketoacidosis. The pyogenic and fungal infections increased significantly in children with poor glycemic control as proved by measuring the glycosylated hemoglobin level [HBA1C] which raises the need for proper geycemic control in IDDM. In conclusion the diabetic children should be regularly followed up and examincd dermatologieally for early detection and treatment of any skin disorder associating IDDM