Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 2 de 2
Filtrar
Adicionar filtros








Intervalo de ano
1.
Indian J Biochem Biophys ; 1999 Aug; 36(4): 248-51
Artigo em Inglês | IMSEAR | ID: sea-28085

RESUMO

The leishmanicidal property of piperine intercalated in liposomes and in mannose-coated liposomes was tested in experimental visceral leishmaniasis in hamsters. Mannose-coated liposomal piperine eliminated intracellular amastigotes of Leishmania donovani in splenic macrophages much more efficiently than did the liposomal piperine or free piperine. At a dose equivalent to 6 mg/kg body wt every 4th day for a total of 4 doses in 12 days, the mannose-coated liposomal piperine was found to reduce spleen parasite load to the extent of 90% in comparison to that achieved by liposomal piperine (77%) or free piperine (29%). Histological examination of spleen and liver function tests showed that the toxicity of piperine was reduced when mannosylated liposomal piperine was administered.


Assuntos
Alcaloides , Animais , Antiprotozoários/administração & dosagem , Benzodioxóis , Cricetinae , Portadores de Fármacos , Leishmaniose Visceral/tratamento farmacológico , Lipossomos , Testes de Função Hepática , Macrófagos/parasitologia , Manose/administração & dosagem , Mesocricetus , Piperidinas/administração & dosagem , Alcamidas Poli-Insaturadas , Baço/parasitologia
2.
Indian J Biochem Biophys ; 1995 Jun; 32(3): 147-51
Artigo em Inglês | IMSEAR | ID: sea-28833

RESUMO

Asiaticoside, a plant glycoside with rhamnose as end sugar and having microbicidal properties was tested against Mycobacterium leprae and Mycobacterium tuberculosis both in vivo and in vitro. As rhamnose is reported to have no tissue specificity, corchorusin D having glucose as end sugar was used for targeting with an equimolar proportion of asiaticoside in liposomal form for testing the drug value. Results showed that liposomal asiaticoside had better microbicidal property against M. leprae and M. tuberculosis when compared to that of free asiaticoside whereas liposomes containing asiaticoside and corchorusin D were found to be equally or more active in comparison to liposomal asiaticoside alone. It is inferred that appropriate glycosides, if used in liposomal form (incorporated or covalently grafted) have enhanced drug efficacy and such glycoside bearing liposomes as targeted delivery systems could be used for chemotherapeutic control of several other diseases.


Assuntos
Animais , Portadores de Fármacos , Feminino , Hanseníase/tratamento farmacológico , Lipossomos , Macrófagos/efeitos dos fármacos , Masculino , Camundongos , Mycobacterium leprae , Mycobacterium tuberculosis , Triterpenos/administração & dosagem , Tuberculose/tratamento farmacológico
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA