RESUMO
Background: Obesity is a leading cause of morbidity and mortality worldwide and is known to arise from an imbalance between energy intake and expenditure,. Hence research into childhood obesity is of paramount importance in preventing obesity-related mortality and morbidity in adults
Objectives: The Aim of the study is Detection of the level of the serum RBP4 and resistin level in obese children, and Evaluation of serum RBP4 and resistin as an indicator of insulin resistance by exploring the possible correlation between serum resistin level, anthropometric measurements and insulin resistance in obese non diabetic children
Methodology: This study is a case-control study included 88 children divided as forty five obese children and young adolescents attending nutrition Clinic, Children's Hospital, Ain shams University From January 2013 to November 2013, Forty three healthy children and young adolescents age and sex matched were included as control subjects. Assessment of BMI was done using categories reported by the World Health Organization [WHO] Child Growth Charts Standards forage and sex [2007]
Results: There was positive correlation between fasting serum RBP4 and anthropometric and clinical data [weight SDS, BMI SDS, waist/hip ratio, systolic, and diastolic blood pressure], laboratory data [Fasting serum insulin, HOMA-IR, total cholesterol, LDL-c], body composition data [body fat percent, fat mass and fat free mass], There were significant negative correlations between resistin and weight, BMI, cholesterol, triglycerides, LDL and TBF%, msulin and HOMA-IR, SBP, DBP, BMR in case group. There were significant positive correlations between resistin and EDL and TBW% in the case group
Conclusion: RBP4 is positivity correlated to serum insulin level, HOMA/IR, and lipid profile, so RBP4 can be used as a marker for insulin resistance and obesity, Studies with large sample size and high power are needed to explain the link between resistin and obesity associated insulin resistance especially in children
RESUMO
In this study, 60 male albino rats [average weight 100-150 g] were used. They were randomly divided into four groups, each comprised 15 rats: The first group served as a control; rats in the second and third groups were subcutaneously injected with 1,2 dimethylhydrazine [DMH] 20 mg/kg b.w. once a week for 20 weeks as well as rats in the third and fourth groups were orally administered celecoxib 20 mg/kg b.w. daily for 20 weeks. At the end of the trial, all animals were sacrificed to study the possible effects of selective cox-2 inhibitor on induced colon cancer tumor cell proliferation, angiogenesis and migration in the experimental animals. Colons, livers and lungs were taken, put in 10% neutral formalin, processed and stained for histopathological and immunohistopathological study. The tumor incidence in DMH treated group [2nd group] was 100%. Celecoxib + DMH treated group had fewer tumors and less angiogenesis compared with DMH treated group and control group [4th and 1st group]. Also, liver and lung metastasis were less in celecoxib + DMH treated group than the DMH treated group