overview of thyroid cancer management in Kuwait cancer control centre [1992-1998]

thyroid cancer in Kuwait is the second most common malignant neoplasm after breast cancer in females. This retrospective single-institution study aims at assessing the different surgical treatment options offered to thyroid cancer patients presenting to Kuwait Cancer Control Centre [KCCC] between March 1992 and June 1998 and evaluating patients outcome. Patients and a total of 197 consecutive patients with clinicaly suspicious thyroid nodules were primarily treated by surgery at KCCC in the above mentioned period; 86 [44%] patients were proved have thyroid malignancy. Clinical characteristics, histological features, prognostic factors, the impact of various surgical procedures on patient outcome along with treatment-related morbidities were all analysed. fifty-nine patients were females and 27 males. The majority of our patients were below the age of 45 years, while 25 were at the age of 45 or above. The mean age was 40 years. Sixty-two [72%] patients presented with true solitary thyroid nodules. Eleven [13%] patients had distant metastasis at presentation. In this series, there was no underlying toxic goitre of Hashimoto's disease. Adequate information for cancer staging, according to the Internation Union Against Cancer [UICC-TNM] classification, was available in 54 [63%] patients. The most common histological type was papillary carcinoma, documented in 74 [86%] patients. The type and extent of thyroid surgery were planned according to the age at the time of initial diagnosis, histological tumour type, size and presence of extra-thyroid invasion, sixty-five [76%] patients had total extracapsular thyroidectomy, 12 [14%] near total thyroidectomy, 7 [8%] ipsilateral total lobectomy and isthmectomy and 2 [2%] contralateral thyroid lobetomy. Different types of therapeutic neck dissections were carried out in 48 [56%] cases. Following surgery, 4 [5%] patients had chronic shoulder pain syndrome, 5 [6%] patients had transient hypocalcaemia, 3 [3%] permanent hypocalcaemia, and 5 [6%] unilateral temporary paresis of the recurrent laryngeal nerve [RLN]; in one patient, the RLN was sacrificed on one side due to an extensive tumour growth. total thyroidectomy remains the treatment of choice for patient with differentiated thyroid carcinoma, due to its excellent local control with a minimal morbidity rate. However, ipsilateral thyroid lobectomy and isthmectomy can be recommended for young, low-risk patients. Patients with palpable medullary thyroid carcinoma should have an aggressive surgical treatment in the form of total thyroidectomy with routine central lymph node clearance and bilateral functional neck dissections

effects of topical prostaglandin E2 on the nasal blood vessels. A study on patients with allergic rhinitis

In the present work, the effects of topical prostaglandin E2 [dinoprostone] on the nasal blood vessels of patients with allergic rhinitis were studied. The outstanding changes were constriction of the arterioles and capillaries [to a lesser extent] and tight closure of the interendothelial junctions. These changes caused a diminution of nasal blood flow and edema formation, a reduction in the size of the turbinates and consequently an increase in nasal patency. However, the drug had no effect on the nasal venules. The present research revealed the possibility of using dinoprostone topically to relieve nasal obstruction in allergic patients