RESUMO
Objective: To measure the synergistic effects of Aloe vera and Rosiglitazone on blood glucose, insulin and insulin insensitivity in non-insulin dependent diabetes mellitus
Study Design: Randomized control trail study
Place and Duration of Study: This study was conducted at Army Medical College, Rawalpindi in the Physiology Department from January 2009 to September, 2010 in alliance with National Institute of Health [NIH] Islamabad
Materials and Methods: Thirty healthy rats were made diabetic according to Srinivasan model. After confirming type 2 diabetes in them they were randomly segregated into two equal groups. The groups named diabetic were injected with normal saline and other combined group were given 150mg/kg body weight of Aloe vera extract and 2.5mg/kg body weight of rosiglitazone diabetic group. It was half their effective dose as their effective dose was calculated through pilot study
Results: Plasma glucose, insulin, and TG/HDL ratio were significantly reduced [p<0.0000001] in combined group then diabetic control group
Conclusion: The significant result was obtained in combined group in lowering plasma glucose, insulin and insulin resistance though half their effective doses were used. It will also help in reducing side effects associated with use of rosiglitazone
RESUMO
Objective: To determine frequency of ABO and Rh [D] blood groups among blood donors in district Swabi
Study Design: Observational / descriptive study
Place and Duration of Study: The study was conducted at BGKMC Hospital in collaboration with physiology Department, GKMC from 1[st] January 2015 to 31[st] December 2015
Materials and Methods: A total of 2120 healthy adult, blood donors [both volunteer and directed] from district Swabi were included. The data was collected from the record of Bacha Khan Group of Teaching hospitals in collaboration with department of Physiology
Results: Among ABO blood groups "B" [31.42%] was the most prevalent, followed by "A" [30.47%], "O" [29.53%] and "AB" [8.58%]. Group Rh positive [93.11%] was more prevalent than Rh negative [6.88%]. Similarly B[+ive] [28.76%] was most frequent followed by A[+ive] [28.41%], O[+ive] [27.64%], AB[+ive] [8.3%], B[-ive] [2.64%], A[- ive][2.08%], O[-ive][ 1.89%] and AB[-ive] [ 0.28%]
Conclusion: Blood group 'B' was most frequent among the ABO blood groups and Rh [D] positive among Rh blood groups while B[+ive] was the most frequent blood group in the study population
RESUMO
Objective: To determine the effect of Aloe vera whole leaf extract and/or Rosiglitazone on plasma glucose, insulin and insulin resistance in type 2 diabetic Sprague-Dawley rats
Study Design: Randomized control trail
Place and Duration of Study: This study was conducted at the Department of Physiology Army Medical College, Rawalpindi in collaboration with National Institute of Health [NIH] Islamabad from April 2009 to Oct 2010
Materials and Methods: Type 2 DM was induced in 45 healthy Sprague -Dawley rats by feeding high fat diet for 2 weeks and injecting a low dose [35mg/kg] of streptozotocin intra peritoneally. Type 2 diabetic rats were randomly divided into three groups, each group having 15 rats and were labeled as diabetic group, Aloe vera group and rosiglitazone group. The diabetic group was injected normal saline, Aloe vera group was treated with Aloe vera whole leaf extract in dose of 300mg/kg body weight and rosiglitazone group was given 5mg/kg body weight of rosiglitazone I/P for 21 days
Results: A significant reduction [p<0.001] in plasma glucose [62%], insulin [19%] and TG/HDL ratio [69%] was analyzed in Aloe Vera group as compared to diabetic control group
Conclusion: The maximum impact in lowering plasma glucose, insulin and TG/HDL ratio was recorded in rosiglitazone group, followed by Aloe vera group. The results of present study provide a scientific basis of using Aloe vera whole leaf extract as antidiabetic in T2DM
RESUMO
Objective To determine the effect of Aloe vera whole leaf extract on lipid profile in type 2 diabetic rats
Study Design: Randomized control trail
Place and Duration of Study: This study was conducted at the Department of Physiology Army Medical College, Rawalpindi in collaboration with National Institute of Health [NIH] Islamabad from April 2009 to Oct 2010
Materials and Methods: Type 2 DM was induced in 45 healthy rats by feeding high fat diet for 2 weeks and injecting a low dose [35mg/kg] of streptozotocin intra peritoneally. Type 2 diabetic rats were randomly divided into three groups, each group having 15 rats and were labeled as diabetic group, Aloe vera group and rosiglitazonegroup. The diabetic group was injected normal saline, Aloe vera group was treated with Aloe vera whole leaf extract in dose of 300mg/kg body weight and rosiglitazone group was given 5mg/kg body weight of rosiglitazone I/P for 21 days
Results: A significant reduction resulted in triglycerides [50%], total cholesterol [49%], low density lipoprotein [57%],, very low density lipoprotein [50%], and increase in high density lipoprotein [50%]. The results of present study provide a scientific basis of using Aloe vera whole leaf extract as lipid lowering drug to reduce the complication and mortality associated with DM
Conclusion: The maximum impact was recorded in rosiglitazone group followed by Aloevera group