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Rutin,a flavonoid found in fruits and vegetables,is a potential anticancer compound with strong anti-cancer activity.Therefore,electrochemical sensor was developed for the detection of rutin.In this study,CoWO4 nanosheets were synthesized via a hydrothermal method,and porous carbon(PC)was prepared via high-temperature pyrolysis.Successful preparation of the materials was confirmed,and character-ization was performed by transmission electron microscopy,scanning electron microscopy,and X-ray photoelectron spectroscopy.A mixture of PC and CoWO4 nanosheets was used as an electrode modifier to fabricate the electrochemical sensor for the electrochemical determination of rutin.The 3D CoWO4 nanosheets exhibited high electrocatalytic activity and good stability.PC has a high surface-to-volume ratio and superior conductivity.Moreover,the hydrophobicity of PC allows large amounts of rutin to be adsorbed,thereby increasing the concentration of rutin at the electrode surface.Owing to the syn-ergistic effect of the 3D CoWO4 nanosheets and PC,the developed electrochemical sensor was employed to quantitively determine rutin with high stability and sensitivity.The sensor showed a good linear range(5-5000 ng/mL)with a detection limit of O.45 ng/mL.The developed sensor was successfully applied to the determination of rutin in crushed tablets and human serum samples.
RESUMO
Objective:To analyze the work status, existing problems and development strategy of clinical pharmaceutics of Chinese medicine. Methods:The literatures on clinical pharmaceutics of Chinese medicine in recent years were comprehensively analyzed to summarize the present situation, find out the existing problems and difficult points and put forward the development strategy. Results:At present, the main work performed in clinical pharmaceutics of Chinese medicine was as follows:clinical pharmacist of Chinese med-icine made the rounds of the wards in clinics, wrote the medication records, studied the pharmacokinetics of traditional Chinese medi-cine ( TCM) and monitored the therapeutic drugs, monitored and intervened the adverse reactions of TCM, carried out the prescription comment on TCM, studied the boiling, administration and processing methods of TCM, performed the clinical pharmaceutical service and pharmaceutical information service of TCM, and researched the pharmaceutical economics and evidence-based medicine of TCM. Conclusion:Significant achievement and development in clinical pharmaceutics of Chinese medicine have been achieved. However, some problems and deficiency still exist, which should be improved and standardized. The paper puts forward some strategies and thoughts for the improvement of clinical pharmaceutics of Chinese medicine for the purpose of providing reference for the comprehensive development of clinical pharmaceutics of Chinese medicine.