RESUMO
Four new corynanthe-type alkaloids, meloslines C-F (1-4), together with four known ones (5-8) were isolated from the roots of Alstonia scholaris. Their structures including absolute configurations were elucidated by extensive spectroscopic analysis and electronic circular dichroism (ECD) calculation. Compounds 1 and 2 exhibited potent vasorelaxant activity on endothelium-intact renal arteries precontracted with KCl.
RESUMO
Objective :To explore ultrasound imaging performance of syphilis-induced cardiovascular diseases and its diagnostic value .Methods : Ultrasound imaging data of 48 patients with syphilitic cardiovascular disease (syphilis group) ,who were diagnosed and treated in our hospital ,were retrospectively analyzed .They were compared with those of 48 healthy subjects (healthy control group) ,their main manifestations : heart valve thickness and aortic di-ameter etc .were analyzed .Results :Main echocardiographic manifestations of syphilis group were valvular changes , aortic regurgitation ,atrioventricular cavity changes ,and reduced myocardial function etc .;compared with healthy control group ,there were significant rise in thickness of left coronary valve [ (20.5 ± 5.2) mm vs.(25.9 ± 3.2) mm] ,right coronary valve [ (21.2 ± 4.7) mm vs .(25.3 ± 3.9) mm] ,no coronary valve [ (20.9 ± 4.2) mm vs . (24.9 ± 4.4) mm] ,mitral anterior lobe [ (28.3 ± 5.1) mm vs.(35.1 ± 5.8) mm] ,tricuspid anterior lobe [ (24.9 ± 3.7) mm vs.(28.2 ± 4.1) mm] and diaphragmatic lobe [ (22.1 ± 2.8) mm vs.(27.2 ± 3.4) mm , P＝0.001 all] , aortic root diameter [ (27.2 ± 3.1) mm vs.(31.3 ± 5.1) mm] and ascending artery diameter [ (26.9 ± 5.4) mm vs. (33.4 ± 6.3) mm] in syphilis group , P＝0.001 both .Conclusion : Ultrasound examination possesses important diag-nostic value for syphilis-induced cardiovascular disease .Heart valve thickness ,aortic root diameter ,and ascending artery diameter increase are important manifestations of its ultrasound imaging .