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【Objective】 To investigate the compatibility of human albumin and its internal packaging materials of Sinopharm Lanzhou Biopharmaceutical Co., Ltd. 【Methods】 One batch of inner packaging materials (medium borosilicate glass-molded injection bottle and halogenated butyl rubber plug for injection) was extracted with 4 extraction solvents to conduct the toxicological evaluation of potential inner packaging extracts. Through the simulated acceleration test, the trend analysis of the elements in the sample and the inner surface of the glass bottle were observed, and the routine drug inspection items during the long-term stability test process were determined. 【Results】 The detection results of the leaching elements of the internal packaging materials did not exceed the limit of 50%, and the organic matter safety threshold (margin of safety, MOS) was greater than 1.0, indicating that both the leaching elements and the organic matter had no safety risk to the user under the current exposure. The results of the simulated acceleration test show that the drug will not have the risk of peeling tablets after the long-term stability condition was placed for a period of time, and the routine inspection items of the long-term stability test drugs all meet the requirements of the pharmacopoeia. 【Conclusion】 The inner packaging material has no significant impact on the quality of drugs and has good overall compatibility, making it suitable for packaging human albumin.
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OBJECTIVE:To evaluate therapeutic efficacy and safety of romethamine for assisted prevention of intraoperative and postoperative hemorrhage in placenta previa puerperal during caesarean section,and to provide evidence-based reference in clinic. METHODS:Retrieved from CNKI,Wanfang database,VIP,CBM and PubMed,randomized controlled trials(RCT)about romethamine(trial group)vs. routine therapy alone,or routine therapy combined(with)misoprostol(control group)for assisted prevention of intraoperative and postoperative hemorrhage in placenta previa puerperal during caesarean section were collected. Meta-analysis was conducted by using Rev Man 5.2 statistical software after data extraction and quality evaluation with Cochrane system evaluator manual 5.2.0. RESULTS:A total of 18 RCTs were included finally,involving 1 824 patients. Results of Meta-analysis showed that intraoperative bleeding amount[MD=-138.16,95%CI(-162.97,-113.35),P<0.001],bleeding amount 2 h after surgery[MD=-134.33,95%CI(-149.87,-118.79),P<0.001],bleeding amount 24 h after surgery[MD=-150.78,95%CI(-171.20,-130.37),P<0.001] and the incidence of postoperative hemorrhage [OR=0.22,95%CI(0.10,0.47),P<0.001] in trial group were significantly lower than control group,with statistical significance. The incidence of ADR in trial group was significantly lower than control group [OR=2.37,95% CI(1.09,5.17),P=0.03],with statistical significance. CONCLUSIONS:Romethamine can reduce intraoperative and postoperative bleeding amount in placenta previa puerperal during caesarean section, and do not increase the occurrence of ADR.
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Extensive attention was paid on how to ensure the cultivation quality for postgraduates with professional degree under the background of the enrollment expansion.The problems in the cultivation of postgraduates with professional degree including declined quality among enrolled students,inefficient training program,unsound management system and little clinical operation chance were analyzed combined with the practice and explore in the clinical competence training for postgraduates with professional degree in Guangxi university of Traditional Chinese Medicine.Some countermeasures were put forward in improving clinical competence for postgraduates with professional degree,for instance the improvement of the management system,tutor team,quality supervision system,clinical skill training and the construction of training bases.
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Objective To discuss the impact of zedoary turmerie oil(ZTO) injection over oncosis index and Bcl-2 expression of human ovarian cancer SKOV3 cell.Methods After ZTO injection acted on human ovarian cancer SKOV3 cells,the changes in the nucleus were observed by fluorescence microscope,oncosis index was counted by projection electron microscope,the situation of cell DNA breakage was observed by agarose gel electrophoresis,and cell Bcl-2 gene expression was observed by immunohistochemical method.Results After treated by ZTO injection for 48 hours,human ovarian cancer SKOV3 cells shows that oncosis cell was swelling in fluorescence microscope,the volume increased,the membrane area narrowed,the nuclear chromatin expansed.The oncosis index increased with dose-effect relationship,DNA electrophoresis showed diffuse type and Bcl-2 gene expression was down-regulated.Conclusion ZTO injection can increase oncosis index of human ovarian cancer SKOV3 cell with the concentration,and lower Bcl-2 gene expression,which may be one of the mechanisms of ZTO injection caused oncosis of SKOV3 cell.