Adenosine A2A receptor and nervous system diseases / 国际药学研究杂志

Adenosine, which arises from the breakdown of adenosine triphosphate, is extensively distributed in mammalian tis-sues and cells. Adenosine exerts its regulating effects on cell function via binding to the specific membrane receptors. Adenosine receptors are belong to G-protein-coupled receptors and can be subdivided into A1, A2A, A2B and A3 receptors in mammals. Among these receptors, A2A has been demonstrated to be related to pathogenesis of many diseases. In the present review, we focus on the recent progress made in investigating the relationship between A2A and nervous system disorders, which may provide new strategies for treatment of these diseases.