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Objective:To explore the CT features of benign and malignant thymus diseases in order to improve the diagnostic accuracy of thymus diseases in children.Methods:The clinical data and imaging data of children with thymic diseases who underwent CT examination in children′s Hospital Affiliated to Capital Institute of Pediatrics from August 2014 to may 2019 were retrospectively analyzed. There were 32 males and 18 females with an average age of (6±4) years (range 5 days to 14.2 years). According to the clinical diagnosis and/or pathological results, all children were divided into benign group (22 cases) and malignant group (28 cases). The clinical manifestations and CT signs (thymus volume, shape, border, density, internal characteristics, relationship with surrounding structures, enhancement pattern and extent) of benign group and malignant group were summarized and compared.Results:The clinical manifestations of benign group and malignant group were varied, and fever was the most common sign. In the benign group, 8 cases showed thymus deficiency, all of them were diagnosed as primary immunodeficiency disease, and the clinical manifestations were repeated and persistent respiratory tract infection history. In 28 cases of malignant group, 20 cases had peripheral invasion and distant metastasis, including 7 cases of lymph node, 6 cases of pleura, 6 cases of lung, 2 cases of pericardium, 2 cases of liver, 2 cases of spleen, 2 cases of kidney and 1 case of bone. All 6 cases of pleural involvement occurred in children with non Hodgkin′s lymphoma. There were significant differences in CT findings between the two groups ( P<0.05); there were no significant differences in terms of shape, density, internal calcification or cystic change, enhancement pattern and enhancement extent of thymus lesions between the two groups ( P>0.05). Conclusions:Benign lesions of thymus usually manifests as absence or normal size of thymus, well-defined, non-necrotic, no displacement of vessels, no peripheral or distant invasion on CT; whereas malignant lesions are mostly enlarged, well or ill-defined, with internal necrosis and vessel displacement, surrounding or distant invasion. CT manifestations of benign and malignant thymus diseases have featured characteristics, and the combination of clinical manifestations is helpful for the differential diagnosis.
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Objective To study the in situ intestinal absorption behaviors of 3,29-dibenzoyl-karounitriol(DK)in Gualou-Xiebai(GX)extract in rats. Methods A rat in situ single-pass perfusion model was used and the concentrations of the perfusate were determined by HPLC-PDAD to investigate the intestinal absorption site and mechanism. Results The main absorption site of DK in GX extract was jejunum,ileum and colon,and the absorption had no significant difference in the three different segments of rat intes?tine(P>0.05),but was significantly higher than that in duodenum(P0.05). Conclusion DK in GX extract could be absorbed in whole intestinal segment,with the best intestinal absorption site of jejunum,ileum and colon. Its absorbing mechanism may be related to passive diffusion.
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Objective To verify the protective effects of Gualou Xiebai dropping pills(GX)on myocardial ischemia-reperfu?sion injury(MIRI)in rats. Methods After screening the qualified SPF rats were randomly divided into four groups,with 12 in each group. Sham-operated group and model group rats were respectively treated with normal saline,and rats in GX group and compound Danshen dropping pills group were given the corresponding dropping pills equivalent to 22.5 g/kg and 85.05 mg/kg of the crude herb,re?spectively. All groups were administered once a day for 7 successive days. One hour after the last administration,the MIRI models were produced by occluding the left coronary artery for 30 min and releasing the occlusion for 120 min. The changes in ST segment were observed,and the contents of creatine kinase-MB(CK-MB),cardiac troponin-T(CTNT)and myoglobin(MYO)in blood plas?ma were measured. The pathological changes in myocardial tissues were observed by optics and electric-microscope and the percentage of myocardial infarction was measured by detecting the content of Evan blue in myocardium. Results Compared to normal saline in the model group,GX had antagonism to ECG S-T segments elevation in rats with myocardial ischemia,while the contents of CK-MB, MYO,and CTNT in blood plasma declined significantly(P<0.05 or P<0.01);the disorder condition of myocardial cell fiber arrange?ment was improved,and edema between myocardial tissue and cells was relieved;the inflammatory cell infiltration and myocardial ne?crosis in cardiac allograft were significantly alleviated,and the percentage of myocardial infarction was decreased significantly(P<0.01). Conclusion GX may play an important protective role against the MIRI in rats.