RESUMO
Objective To observe the clinical efficacy and adverse reactions of proquazone combined with eperisone in treating tension headache.Methods 285 tension headache patients in our hospital from 2009 to 2011were randomly divided into A,B,C three groups.Group A with 95 cases used only eperisone treatment,while B group with 95 cases used only proquazone.Group C with 95 cases received eperisone combined with proquazone treatment.The frequency of migraine attacks,the attack average time,and VAS score of patients were observed.Results The headache frequency,seizure duration and VAS score of group C was (2.01 ± 1.02) times/week,(4.28 ± 2.14) h,(3.42 ± 1.03) points,which were significantly less than those in group A and group B (t =8.682,7.879,13.396,14.140,16.408,21.481,all P ＜ 0.05).The incidence rate of adverse reaction of group C was 37.89％,that in group A was 36.84％,and group B was 34.73％.The difference among them was not statistically significant(P ＞ 0.05).But the incidence rate of drowsiness and indifferent symptom in group C was significandy higher than A and B group.The difference was statistically significant (x2 =34.381,13.821,all P ＜ 0.05).Conclusion Eperisone combined with proquazone could treat tension headaches well,because it can effectively reduce the frequency of migraine attacks in patients as well as the degree of pain.And it could also alleviate the patients' symptoms.In addition,the combination therapy did not increase the incidence rate of adverse reactions in patients.So it has better security and good cilinical promotion.But it couldn't be proscribed to the people with high-risk occupation for its suppression to CNS.